TY - GEN
T1 - FRET-like fluorophore-nanoparticle complex for highly specific cancer localization
AU - Wang, Jianting
AU - Nantz, Michael H.
AU - Achilefu, Samuel
AU - Kang, Kyung A.
PY - 2010/12/1
Y1 - 2010/12/1
N2 - Fluorophore mediated bio-signal retrieval has been extensively used in molecular imaging. However, only a limited number of fluorophores can be used for humans and their quantum yield is usually low. Another important issue is emitting fluorescence at the disease site, with a minimal non-specific emission at any other sites. Artificial quenching and enhancing of fluorescence was found to be possible by manipulating the distance between a fluorophore and a certain type of nanometal particle. Utilizing this unique property, we have designed a novel, FRET-like, fluorophore-nanoparticle complex. The complex emits fluorescence conditionally only at a disease site at an enhanced level. As a model system, our complex is designed to target breast cancer. As an initial step for developing this cancer locator, fluorescence alteration was studied when a spacer at various lengths is placed between a nanogold particle and a safe fluorophore.
AB - Fluorophore mediated bio-signal retrieval has been extensively used in molecular imaging. However, only a limited number of fluorophores can be used for humans and their quantum yield is usually low. Another important issue is emitting fluorescence at the disease site, with a minimal non-specific emission at any other sites. Artificial quenching and enhancing of fluorescence was found to be possible by manipulating the distance between a fluorophore and a certain type of nanometal particle. Utilizing this unique property, we have designed a novel, FRET-like, fluorophore-nanoparticle complex. The complex emits fluorescence conditionally only at a disease site at an enhanced level. As a model system, our complex is designed to target breast cancer. As an initial step for developing this cancer locator, fluorescence alteration was studied when a spacer at various lengths is placed between a nanogold particle and a safe fluorophore.
UR - http://www.scopus.com/inward/record.url?scp=77949903518&partnerID=8YFLogxK
U2 - 10.1007/978-1-4419-1241-1_59
DO - 10.1007/978-1-4419-1241-1_59
M3 - Conference contribution
C2 - 20204823
AN - SCOPUS:77949903518
SN - 9781441912398
T3 - Advances in Experimental Medicine and Biology
SP - 407
EP - 413
BT - Oxygen Transport to Tissue XXXI
A2 - Takahashi, Eiji
A2 - Bruley, Duane
ER -