Abstract
The molecular genetic events underlying endometrial tumorigenesis are ill-defined at present. We have identified a region on the short arm of chromosome 1 which is frequently deleted in endometrial cancers. The region of deletion has been localized to bands 1p32-33. Deletion of 1p32-33 is seen more frequently in cancers of the highly aggressive papillary serous type than in cancers of the less-aggressive endometrioid type. These data suggest the presence of a tumor suppressor gene on 1p32-33 which is specifically involved in the development of endometrial cancers with poor outcome.
Original language | English |
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Pages (from-to) | 1017-1021 |
Number of pages | 5 |
Journal | Human molecular genetics |
Volume | 5 |
Issue number | 7 |
DOIs | |
State | Published - Jul 1996 |