Frequent deletion of chromosome 1p sequences in an aggressive histologic subtype of endometrial cancer

Martin F. Arlt, Thomas J. Herzog, David G. Mutch, Deborah J. Gersell, Hua Liu, Paul J. Goodfellow

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

The molecular genetic events underlying endometrial tumorigenesis are ill-defined at present. We have identified a region on the short arm of chromosome 1 which is frequently deleted in endometrial cancers. The region of deletion has been localized to bands 1p32-33. Deletion of 1p32-33 is seen more frequently in cancers of the highly aggressive papillary serous type than in cancers of the less-aggressive endometrioid type. These data suggest the presence of a tumor suppressor gene on 1p32-33 which is specifically involved in the development of endometrial cancers with poor outcome.

Original languageEnglish
Pages (from-to)1017-1021
Number of pages5
JournalHuman molecular genetics
Volume5
Issue number7
DOIs
StatePublished - Jul 1 1996

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