TY - JOUR
T1 - Frequency Transitions in Odor-Evoked Neural Oscillations
AU - Ito, Iori
AU - Bazhenov, Maxim
AU - Ong, Rose Chik ying
AU - Raman, Baranidharan
AU - Stopfer, Mark
N1 - Funding Information:
We are grateful to members of the Stopfer and Bazhenov laboratories for helpful discussions and to Dr. Marit Stranden for sensilla lessons. We also thank Dr. Kui Sun for her excellent animal care. Microscopy imaging was performed at the Microscopy & Imaging Core (National Institute of Child Health and Human Development, NIH) with the kind assistance of Dr. Vincent Schram. This work was supported by the Japan Society for the Promotion of Science (00169, 70510) to I.I., Joint NIH-NIST postdoctoral fellowship award by National Research Council to B.R., grants from NIH-NIDCD and NIH-NINDS to M.B. and an intramural grant from NIH-NICHD to M.S.
PY - 2009/12/10
Y1 - 2009/12/10
N2 - In many species, sensory stimuli elicit the oscillatory synchronization of groups of neurons. What determines the properties of these oscillations? In the olfactory system of the moth, we found that odors elicited oscillatory synchronization through a neural mechanism like that described in locust and Drosophila. During responses to long odor pulses, oscillations suddenly slowed as net olfactory receptor neuron (ORN) output decreased; thus, stimulus intensity appeared to determine oscillation frequency. However, changing the concentration of the odor had little effect upon oscillatory frequency. Our recordings in vivo and computational models based on these results suggested that the main effect of increasing odor concentration was to recruit additional, less well-tuned ORNs whose firing rates were tightly constrained by adaptation and saturation. Thus, in the periphery, concentration is encoded mainly by the size of the responsive ORN population, and oscillation frequency is set by the adaptation and saturation of this response.
AB - In many species, sensory stimuli elicit the oscillatory synchronization of groups of neurons. What determines the properties of these oscillations? In the olfactory system of the moth, we found that odors elicited oscillatory synchronization through a neural mechanism like that described in locust and Drosophila. During responses to long odor pulses, oscillations suddenly slowed as net olfactory receptor neuron (ORN) output decreased; thus, stimulus intensity appeared to determine oscillation frequency. However, changing the concentration of the odor had little effect upon oscillatory frequency. Our recordings in vivo and computational models based on these results suggested that the main effect of increasing odor concentration was to recruit additional, less well-tuned ORNs whose firing rates were tightly constrained by adaptation and saturation. Thus, in the periphery, concentration is encoded mainly by the size of the responsive ORN population, and oscillation frequency is set by the adaptation and saturation of this response.
KW - SYSNEURO
UR - http://www.scopus.com/inward/record.url?scp=71149119588&partnerID=8YFLogxK
U2 - 10.1016/j.neuron.2009.10.004
DO - 10.1016/j.neuron.2009.10.004
M3 - Article
C2 - 20005825
AN - SCOPUS:71149119588
SN - 0896-6273
VL - 64
SP - 692
EP - 706
JO - Neuron
JF - Neuron
IS - 5
ER -