Frequency-specific SSFP for hyperpolarized 13C metabolic imaging at 14.1 T

Cornelius von Morze; Subramaniam Sukumar; Galen D. Reed; Peder E.Z. Larson; Robert A. Bok; John Kurhanewicz; Daniel B. Vigneron

doi:10.1016/j.mri.2012.06.037

Frequency-specific SSFP for hyperpolarized ¹³C metabolic imaging at 14.1 T

Cornelius von Morze, Subramaniam Sukumar, Galen D. Reed, Peder E.Z. Larson, Robert A. Bok, John Kurhanewicz, Daniel B. Vigneron

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Metabolic imaging of hyperpolarized [1-¹³C] pyruvate co-polarized with [¹³C]urea by dynamic nuclear polarization with rapid dissolution is a promising new method for assessing tumor metabolism and perfusion simultaneously in vivo. Novel pulse sequences are required to enable dynamic imaging of multiple ¹³C spectral lines with high spatiotemporal resolution. The goal of this study was to investigate a new frequency-specific approach for rapid metabolic imaging of multiple ¹³C resonances using the spectral selectivity of steady-state free precession pulse (SSFP) trains. Methods developed in simulations were implemented in a dynamic frequency-cycled balanced SSFP pulse sequence on a 14.1-T animal magnetic resonance imaging scanner. This acquisition was tested in thermal and hyperpolarized phantom imaging studies and in a transgenic mouse with prostate cancer.

Original language	English
Pages (from-to)	163-170
Number of pages	8
Journal	Magnetic Resonance Imaging
Volume	31
Issue number	2
DOIs	https://doi.org/10.1016/j.mri.2012.06.037
State	Published - Feb 2013

Keywords

C
DNP
Hyperpolarized
Metabolic imaging
Pyruvate
SSFP
Urea

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10.1016/j.mri.2012.06.037

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title = "Frequency-specific SSFP for hyperpolarized 13C metabolic imaging at 14.1 T",

abstract = "Metabolic imaging of hyperpolarized [1-13C] pyruvate co-polarized with [13C]urea by dynamic nuclear polarization with rapid dissolution is a promising new method for assessing tumor metabolism and perfusion simultaneously in vivo. Novel pulse sequences are required to enable dynamic imaging of multiple 13C spectral lines with high spatiotemporal resolution. The goal of this study was to investigate a new frequency-specific approach for rapid metabolic imaging of multiple 13C resonances using the spectral selectivity of steady-state free precession pulse (SSFP) trains. Methods developed in simulations were implemented in a dynamic frequency-cycled balanced SSFP pulse sequence on a 14.1-T animal magnetic resonance imaging scanner. This acquisition was tested in thermal and hyperpolarized phantom imaging studies and in a transgenic mouse with prostate cancer.",

keywords = "C, DNP, Hyperpolarized, Metabolic imaging, Pyruvate, SSFP, Urea",

author = "{von Morze}, Cornelius and Subramaniam Sukumar and Reed, {Galen D.} and Larson, {Peder E.Z.} and Bok, {Robert A.} and John Kurhanewicz and Vigneron, {Daniel B.}",

note = "Funding Information: We gratefully acknowledge grant support from the National Institutes of Health (grant P41EB013598 ).",

year = "2013",

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doi = "10.1016/j.mri.2012.06.037",

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volume = "31",

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AU - von Morze, Cornelius

AU - Sukumar, Subramaniam

AU - Reed, Galen D.

AU - Larson, Peder E.Z.

AU - Bok, Robert A.

AU - Kurhanewicz, John

AU - Vigneron, Daniel B.

N1 - Funding Information: We gratefully acknowledge grant support from the National Institutes of Health (grant P41EB013598 ).

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N2 - Metabolic imaging of hyperpolarized [1-13C] pyruvate co-polarized with [13C]urea by dynamic nuclear polarization with rapid dissolution is a promising new method for assessing tumor metabolism and perfusion simultaneously in vivo. Novel pulse sequences are required to enable dynamic imaging of multiple 13C spectral lines with high spatiotemporal resolution. The goal of this study was to investigate a new frequency-specific approach for rapid metabolic imaging of multiple 13C resonances using the spectral selectivity of steady-state free precession pulse (SSFP) trains. Methods developed in simulations were implemented in a dynamic frequency-cycled balanced SSFP pulse sequence on a 14.1-T animal magnetic resonance imaging scanner. This acquisition was tested in thermal and hyperpolarized phantom imaging studies and in a transgenic mouse with prostate cancer.

AB - Metabolic imaging of hyperpolarized [1-13C] pyruvate co-polarized with [13C]urea by dynamic nuclear polarization with rapid dissolution is a promising new method for assessing tumor metabolism and perfusion simultaneously in vivo. Novel pulse sequences are required to enable dynamic imaging of multiple 13C spectral lines with high spatiotemporal resolution. The goal of this study was to investigate a new frequency-specific approach for rapid metabolic imaging of multiple 13C resonances using the spectral selectivity of steady-state free precession pulse (SSFP) trains. Methods developed in simulations were implemented in a dynamic frequency-cycled balanced SSFP pulse sequence on a 14.1-T animal magnetic resonance imaging scanner. This acquisition was tested in thermal and hyperpolarized phantom imaging studies and in a transgenic mouse with prostate cancer.

KW - C

KW - DNP

KW - Hyperpolarized

KW - Metabolic imaging

KW - Pyruvate

KW - SSFP

KW - Urea

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ER -

Frequency-specific SSFP for hyperpolarized ¹³C metabolic imaging at 14.1 T

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Keywords

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