Frequency and Clinical Significance of Localized Adverse Events following Mass Drug Administration for Lymphatic Filariasis in an Endemic Area in South India

Vijesh Sreedhar Kuttiatt, Roopali K. Somani, Subramanian Swaminathan, Kaliannagounder Krishnamoorthy, Gary J. Weil, Jambulingam Purushothaman

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Fear of adverse events (AEs) negatively affects compliance to mass drug administration (MDA) for lymphatic filariasis (LF) elimination program. Systemic AEs are believed to occur because of killing of microfilariae, whereas localized soft tissue reactions might be due to the death of adult worms following therapy. Most AEs are mild and self-limited. However, localized AEs are sometimes more significant and of concern to participants. Here, we describe localized AEs that were noted during a large community study that evaluated the safety of a triple-drug regimen (ivermectin, diethylcarbamazine, and albendazole) for the treatment of LF in India. We have also discussed the importance of timely detection and careful management of AEs for preserving community confidence in MDA.

Original languageEnglish
Pages (from-to)96-99
Number of pages4
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume102
Issue number1
DOIs
StatePublished - 2020

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