Free β-human chorionic gonadotropin, total human chorionic gonadotropin and maternal risk of breast cancer

Adetunji T. Toriola, Egle Tolockiene, Helena Schock, Helja Marja Surcel, Anne Zeleniuch-Jacquotte, Goran Wadell, Paolo Toniolo, Eva Lundin, Kjell Grankvist, Annekatrin Lukanova

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6 Scopus citations

Abstract

Background: We investigated whether the free β-human chorionic gonadotropin (free β-hCG) would provide additional information to that provided by total hCG alone and thus be useful in future epidemiological studies relating hCG to maternal breast cancer risk. Materials & methods: Cases (n = 159) and controls (n = 286) were a subset of our previous study within the Northern Sweden Maternity Cohort on total hCG during primiparous pregnancy and breast cancer risk. Results: The associations between total hCG (hazard ratio: 0.79; 95% CI: 0.49-1.27), free β-hCG (hazard ratio: 0.85; 95% CI: 0.33-2.18) and maternal risk of breast cancer were very similar in all analyses and mutual adjustment for either one had minor effects on the risk estimates. Conclusion: In the absence of a reliable assay on intact hCG, total hCG alone can be used in epidemiological studies investigating hCG and breast cancer risk, as free β-hCG does not appear to provide any additional information.

Original languageEnglish
Pages (from-to)377-384
Number of pages8
JournalFuture Oncology
Volume10
Issue number3
DOIs
StatePublished - Feb 1 2014

Keywords

  • Breast cancer
  • Free β-human chorionic gonadotropin
  • Human chorionic gonadotropin
  • Nested case-control study
  • Pregnancy

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    Toriola, A. T., Tolockiene, E., Schock, H., Surcel, H. M., Zeleniuch-Jacquotte, A., Wadell, G., Toniolo, P., Lundin, E., Grankvist, K., & Lukanova, A. (2014). Free β-human chorionic gonadotropin, total human chorionic gonadotropin and maternal risk of breast cancer. Future Oncology, 10(3), 377-384. https://doi.org/10.2217/fon.13.208