Fragile-like regulatory T cells modulate opioid withdrawal in humans and mice

Marwa O. Mikati; Robyn S. Klein

doi:10.1016/j.immuni.2023.01.021

Fragile-like regulatory T cells modulate opioid withdrawal in humans and mice

Marwa O. Mikati
, Robyn S. Klein

Research output: Contribution to journal › Comment/debate

5 Scopus citations

Abstract

Opioid use alters peripheral immune functions via unknown mechanisms. In a recent issue of Cell, Zhu et al. report increased fragile-like regulatory T cells in patients with opioid use disorder and in morphine-treated mice. In mice, Treg cell-derived interferon-γ within the brain promotes withdrawal-associated alterations in synapses.

Original language	English
Pages (from-to)	237-239
Number of pages	3
Journal	Immunity
Volume	56
Issue number	2
DOIs	https://doi.org/10.1016/j.immuni.2023.01.021
State	Published - Feb 14 2023

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title = "Fragile-like regulatory T cells modulate opioid withdrawal in humans and mice",

abstract = "Opioid use alters peripheral immune functions via unknown mechanisms. In a recent issue of Cell, Zhu et al. report increased fragile-like regulatory T cells in patients with opioid use disorder and in morphine-treated mice. In mice, Treg cell-derived interferon-γ within the brain promotes withdrawal-associated alterations in synapses.",

author = "Mikati, \{Marwa O.\} and Klein, \{Robyn S.\}",

note = "Publisher Copyright: {\textcopyright} 2023 Elsevier Inc.",

year = "2023",

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AU - Mikati, Marwa O.

AU - Klein, Robyn S.

PY - 2023/2/14

Y1 - 2023/2/14

N2 - Opioid use alters peripheral immune functions via unknown mechanisms. In a recent issue of Cell, Zhu et al. report increased fragile-like regulatory T cells in patients with opioid use disorder and in morphine-treated mice. In mice, Treg cell-derived interferon-γ within the brain promotes withdrawal-associated alterations in synapses.

AB - Opioid use alters peripheral immune functions via unknown mechanisms. In a recent issue of Cell, Zhu et al. report increased fragile-like regulatory T cells in patients with opioid use disorder and in morphine-treated mice. In mice, Treg cell-derived interferon-γ within the brain promotes withdrawal-associated alterations in synapses.

UR - https://www.scopus.com/pages/publications/85147819263

U2 - 10.1016/j.immuni.2023.01.021

DO - 10.1016/j.immuni.2023.01.021

M3 - Comment/debate

C2 - 36792570

AN - SCOPUS:85147819263

SN - 1074-7613

VL - 56

SP - 237

EP - 239

JO - Immunity

JF - Immunity

IS - 2

ER -

Fragile-like regulatory T cells modulate opioid withdrawal in humans and mice

Abstract

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