TY - JOUR
T1 - Fractionating E-wave deceleration time into its stiffness and relaxation components distinguishes pseudonormal from normal filling
AU - Mossahebi, Sina
AU - Zhu, Simeng
AU - Kovács, Sándor J.
N1 - Publisher Copyright:
© 2015 American Heart Association, Inc.
PY - 2014
Y1 - 2014
N2 - Background: Pseudonormal Doppler E-wave filling patterns indicate diastolic dysfunction but are indistinguishable from the normal filling pattern. For accurate classification, maneuvers to alter load or to additionally measure peak E' are required. E-wave deceleration time (DT) has been fractionated into its stiffness (DTs) and relaxation (DTr) components (DT=DTs+DTr) by analyzing E-waves via the parametrized diastolic filling formalism. The method has been validated with DTs and DTr correlating with simultaneous catheterization-derived stiffness (dP/dV) and relaxation (τ) with r=0.82 and r=0.94, respectively. We hypothesize that DT fractionation can (1) distinguish between unblinded (E' known) normal versus pseudonormal age-matched groups with normal left ventricular ejection fraction, and (2) distinguish between blinded (E' unknown) normal versus pseudonormal groups, based solely on E-wave analysis. Methods and Results: Data (763 E-waves) from 15 age-matched, pseudonormal (elevated E/E') and 15 normal subjects were analyzed. Conventional echocardiographic and parametrized diastolic filling stiffness (k) and relaxation (c) parameters and DTs and DTr were compared. Conventional diastolic function parameters did not differentiate between unblinded groups, whereas k, c (P<0.001) and DTs, DTr (P<0.001) did. Independent, blinded (E' not provided) analysis of 42 subjects (30 subjects from unblinded training set and 12 additional subjects from validation set, 581 E-waves) showed that R (=DTr/DT) had high sensitivity (0.90) and specificity (0.86) in differentiating pseudonormal from normal once E' revealed actual classification. Conclusions: Parametrized diastolic filling-based E-wave analysis (k, c or DTs and DTr) can differentiate normal versus pseudonormal filling patterns without requiring knowledge of E'.
AB - Background: Pseudonormal Doppler E-wave filling patterns indicate diastolic dysfunction but are indistinguishable from the normal filling pattern. For accurate classification, maneuvers to alter load or to additionally measure peak E' are required. E-wave deceleration time (DT) has been fractionated into its stiffness (DTs) and relaxation (DTr) components (DT=DTs+DTr) by analyzing E-waves via the parametrized diastolic filling formalism. The method has been validated with DTs and DTr correlating with simultaneous catheterization-derived stiffness (dP/dV) and relaxation (τ) with r=0.82 and r=0.94, respectively. We hypothesize that DT fractionation can (1) distinguish between unblinded (E' known) normal versus pseudonormal age-matched groups with normal left ventricular ejection fraction, and (2) distinguish between blinded (E' unknown) normal versus pseudonormal groups, based solely on E-wave analysis. Methods and Results: Data (763 E-waves) from 15 age-matched, pseudonormal (elevated E/E') and 15 normal subjects were analyzed. Conventional echocardiographic and parametrized diastolic filling stiffness (k) and relaxation (c) parameters and DTs and DTr were compared. Conventional diastolic function parameters did not differentiate between unblinded groups, whereas k, c (P<0.001) and DTs, DTr (P<0.001) did. Independent, blinded (E' not provided) analysis of 42 subjects (30 subjects from unblinded training set and 12 additional subjects from validation set, 581 E-waves) showed that R (=DTr/DT) had high sensitivity (0.90) and specificity (0.86) in differentiating pseudonormal from normal once E' revealed actual classification. Conclusions: Parametrized diastolic filling-based E-wave analysis (k, c or DTs and DTr) can differentiate normal versus pseudonormal filling patterns without requiring knowledge of E'.
KW - Diastole
KW - Doppler echocardiography
KW - Left ventricle
KW - Relaxation
KW - Stiffness
UR - http://www.scopus.com/inward/record.url?scp=84928045283&partnerID=8YFLogxK
U2 - 10.1161/CIRCIMAGING.114.002177
DO - 10.1161/CIRCIMAGING.114.002177
M3 - Article
C2 - 25596141
AN - SCOPUS:84928045283
VL - 8
JO - Circulation: Cardiovascular Imaging
JF - Circulation: Cardiovascular Imaging
SN - 1941-9651
IS - 1
M1 - e002177
ER -