FoxO6 regulates memory consolidation and synaptic function

Dervis A.M. Salih, Asim J. Rashid, Damien Colas, Luis de la Torre-Ubieta, Ruo P. Zhu, Alexander A. Morgan, Evan E. Santo, Duygu Ucar, Keerthana Devarajan, Christina J. Cole, Daniel V. Madison, Mehrdad Shamloo, Atul J. Butte, Azad Bonni, Sheena A. Josselyn, Anne Brunet

Research output: Contribution to journalArticlepeer-review

94 Scopus citations


The FoxO family of transcription factors is known to slow aging downstream from the insulin/IGF (insulin-like growth factor) signaling pathway. The most recently discovered FoxO isoform in mammals, FoxO6, is highly enriched in the adult hippocampus. However, the importance of FoxO factors in cognition is largely unknown. Here we generated mice lacking FoxO6 and found that these mice display normal learning but impaired memory consolidation in contextual fear conditioning and novel object recognition. Using stereotactic injection of viruses into the hippocampus of adult wild-type mice, we found that FoxO6 activity in the adult hippocampus is required for memory consolidation. Genome-wide approaches revealed that FoxO6 regulates a program of genes involved in synaptic function upon learning in the hippocampus. Consistently, FoxO6 deficiency results in decreased dendritic spine density in hippocampal neurons in vitro and in vivo. Thus, FoxO6 may promote memory consolidation by regulating a program coordinating neuronal connectivity in the hippocampus, which could have important implications for physiological and pathological age-dependent decline in memory.

Original languageEnglish
Pages (from-to)2780-2801
Number of pages22
JournalGenes and Development
Issue number24
StatePublished - 2012


  • Consolidation
  • FoxO transcription factors
  • Hippocampus
  • Insulin signaling
  • Learning and memory
  • Synaptic function


Dive into the research topics of 'FoxO6 regulates memory consolidation and synaptic function'. Together they form a unique fingerprint.

Cite this