Four-dimensional computed tomography-based respiratory-gated whole-abdominal intensity-modulated radiation therapy for ovarian cancer: A feasibility study

A. A. Garsa, R. S. Andrade, D. E. Heron, S. Beriwal, H. Kim, E. Brandner, G. Kuo, H. Chen, K. Gerszten, J. N. Yue, M. S. Huq, J. Lee, R. Lalonde, A. Wu

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

This study assesses the feasibility and implementation of respiratory-gated whole-abdominal intensity-modulated radiation therapy (RG-WAIMRT). Three patients were treated with RG-WAIMRT. The planning target volume (PTV1) included the entire peritoneal cavity and a pelvic boost field was created (PTV2). The dose prescribed was 30 Gy to PTV1 and 14.4 Gy to PTV2. For comparison, a conventional three-dimensional (3D) plan was generated for each patient. In the WAIMRT plan, an average of 90% of PTV1 received 30 Gy compared to 70% for the conventional 3D plan. The percent volume receiving 30 Gy (V30) for liver averaged 54% (WAIMRT) vs 43% (3D). The percent volume receiving 20 Gy (V20) for kidneys averaged 19% vs 0%, and the mean V20 for bone marrow was 74% vs 83%, respectively. Major acute toxicities were anemia (grade 2: 1/3), leukopenia (grade 3: 2/3 patients), and thrombocytopenia (grade 2: 1/3 patients, grade 3: 1/3 patients). One patient could not complete the whole-abdomen field after 19.5 Gy because of persistent nausea. No major subacute toxicity has been reported. WAIMRT demonstrated superior target coverage and reduced dose to bone marrow, with a slightly increased dose to liver and kidneys. WAIMRT is a novel and feasible technique for ovarian cancer treatment.

Original languageEnglish
Pages (from-to)55-60
Number of pages6
JournalInternational Journal of Gynecological Cancer
Volume17
Issue number1
DOIs
StatePublished - Jan 1 2007
Externally publishedYes

Keywords

  • 4D CT
  • Ovarian cancer
  • Toxicity
  • Whole-abdominal radiotherapy

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