Four-chamber heart dynamics: Modeling with in vivo validation via MRI

A. W. Bowman, S. D. Caruthers, S. J. Kovács

Research output: Contribution to journalConference articlepeer-review


Previous studies in dogs using the dynamic spatial reconstructor have shown that the total (blood + tissue) volume of the pericardial sack remains constant (within a few percent) throughout the cardiac cycle. Others have reported that pericardial volume in humans remains constant for parts of the cardiac cycle. We use three-dimensional datasets acquired using cardiac MRI to determine the constant-volume attribute of the four-chamber heart. The four-chamber constant-volume attribute is achieved by reciprocal variation of atrial and ventricular volumes, requiring oscillation of the atrioventricular valve plane. We develop a lumped parameter oscillator model having fixed external dimension to model atrioventricular (mitral) valve plane location as a function of time. We conclude that the constant volume attribute of the four-chambered heart is accurate to within 4-6%, and constant-volume based modeling of heart dynamics can predict mitral valve plane displacement throughout the cardiac cycle.

Original languageEnglish
Pages (from-to)1252-1253
Number of pages2
JournalAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
StatePublished - Dec 1 2002
EventProceedings of the 2002 IEEE Engineering in Medicine and Biology 24th Annual Conference and the 2002 Fall Meeting of the Biomedical Engineering Society (BMES / EMBS) - Houston, TX, United States
Duration: Oct 23 2002Oct 26 2002


  • Atrioventricular coupling
  • Cardiac MRI
  • Four-chamber heart function
  • Modeling

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