Foundational Science and Mechanistic Insights for a Shared Disease Model: An Expert Consensus

Developed by the AUGS Basic Science Subcommittee and IUGA Special Interest Group

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Pelvic floor disorders (PFDs) are complex conditions that impact millions of women worldwide. It is estimated that PFDs will affect approximately 30%–50% of women older than 50 years and incur a 20% lifetime risk of undergoing at least 1 surgical procedure to repair either pelvic organ prolapse (POP) or stress urinary incontinence (SUI) by age 80 years.1 The surgical costs alone are estimated to exceed $10 billion annually,1–6 and this does not account for the cost of nonsurgical and conservative treatments. Although a large body of epidemiological literature provides important information regarding the risk factors for PFDs, the pathogenesis of POP and SUI continues to be poorly understood. Consequently, POP and SUI are associated with significant health care expenditure primarily due to lack of preventive measures, high failure rate of available interventions, and the need for retreatments. Furthermore, the long-standing gaps in mechanistic insights into the pathophysiology of POP and SUI represent one of the major barriers to the development of scientifically rational preventive and therapeutic strategies. Women's health across the life span depends on a better understanding of the anatomy and physiology of the female pelvic floor (PF) and the causal links between the multifactorial epidemiological risk factors and POP/SUI.

Original languageEnglish
Pages (from-to)347-350
Number of pages4
JournalFemale Pelvic Medicine and Reconstructive Surgery
Issue number6
StatePublished - Jun 1 2022


  • aging
  • biomechanics of the female pelvic floor
  • impact of hormonal milieu on the female pelvic floor structure and function
  • pelvic floor disorders
  • pelvic floor structural anatomy and mechanism of disease
  • pelvic organ prolapse
  • stress urinary incontinence


Dive into the research topics of 'Foundational Science and Mechanistic Insights for a Shared Disease Model: An Expert Consensus'. Together they form a unique fingerprint.

Cite this