Formation of nanogel aggregates by an amphiphilic cholesteryl- poly(amidoamine) dendrimer in aqueous media

Donghui Zhang; Paul D. Hamilton; Jeff L.F. Kao; Shrinivas Venkataraman; Karen L. Wooley; Nathan Ravi

doi:10.1002/pola.21958

Formation of nanogel aggregates by an amphiphilic cholesteryl- poly(amidoamine) dendrimer in aqueous media

Donghui Zhang, Paul D. Hamilton, Jeff L.F. Kao, Shrinivas Venkataraman, Karen L. Wooley, Nathan Ravi

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Synthesis process of nanogel aggregates by an hydroxyl poly(amidoamine) amphiphiles containing rigid lipids in which the degree of hydrophobicity was controlled so they remained water soluble, is discussed. The amphiphilic cholesteryl-poly(amidoamine) dendrimer (Ch-G5OH) was prepared by conjugating cholesteryl chloroformate with generation five hydroxyl-terminated poly(amidoamine) dendrimer in the presence of triethylamine (Et₃N) in a particular ratio of dendrimer hydroxyl groups to cholesteryl chloroformate. The amphiphile was found easily dissolvable in water, producing a clear aqueous solution with stable foams on shaking. TEM image of the Ch-G5OH amphiphile cast from a sonicated aqueous solution showed a globular aggregation with an average diameter of 13 nm. The amphiphile aggregation was found to be dependent on exterior conditions such as solvent, dialysis, sonication, and temperature.

Original language	English
Pages (from-to)	2569-2575
Number of pages	7
Journal	Journal of Polymer Science, Part A: Polymer Chemistry
Volume	45
Issue number	12
DOIs	https://doi.org/10.1002/pola.21958
State	Published - Jun 15 2007

Keywords

Amphiphiles
Cholesteryl
Dendrimers
Hydrophobic interactions
Nanogels
Poly(amidoamine) dendrimer

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10.1002/pola.21958

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title = "Formation of nanogel aggregates by an amphiphilic cholesteryl- poly(amidoamine) dendrimer in aqueous media",

abstract = "Synthesis process of nanogel aggregates by an hydroxyl poly(amidoamine) amphiphiles containing rigid lipids in which the degree of hydrophobicity was controlled so they remained water soluble, is discussed. The amphiphilic cholesteryl-poly(amidoamine) dendrimer (Ch-G5OH) was prepared by conjugating cholesteryl chloroformate with generation five hydroxyl-terminated poly(amidoamine) dendrimer in the presence of triethylamine (Et3N) in a particular ratio of dendrimer hydroxyl groups to cholesteryl chloroformate. The amphiphile was found easily dissolvable in water, producing a clear aqueous solution with stable foams on shaking. TEM image of the Ch-G5OH amphiphile cast from a sonicated aqueous solution showed a globular aggregation with an average diameter of 13 nm. The amphiphile aggregation was found to be dependent on exterior conditions such as solvent, dialysis, sonication, and temperature.",

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author = "Donghui Zhang and Hamilton, {Paul D.} and Kao, {Jeff L.F.} and Shrinivas Venkataraman and Wooley, {Karen L.} and Nathan Ravi",

year = "2007",

month = jun,

day = "15",

doi = "10.1002/pola.21958",

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T1 - Formation of nanogel aggregates by an amphiphilic cholesteryl- poly(amidoamine) dendrimer in aqueous media

AU - Zhang, Donghui

AU - Hamilton, Paul D.

AU - Kao, Jeff L.F.

AU - Venkataraman, Shrinivas

AU - Wooley, Karen L.

AU - Ravi, Nathan

PY - 2007/6/15

Y1 - 2007/6/15

N2 - Synthesis process of nanogel aggregates by an hydroxyl poly(amidoamine) amphiphiles containing rigid lipids in which the degree of hydrophobicity was controlled so they remained water soluble, is discussed. The amphiphilic cholesteryl-poly(amidoamine) dendrimer (Ch-G5OH) was prepared by conjugating cholesteryl chloroformate with generation five hydroxyl-terminated poly(amidoamine) dendrimer in the presence of triethylamine (Et3N) in a particular ratio of dendrimer hydroxyl groups to cholesteryl chloroformate. The amphiphile was found easily dissolvable in water, producing a clear aqueous solution with stable foams on shaking. TEM image of the Ch-G5OH amphiphile cast from a sonicated aqueous solution showed a globular aggregation with an average diameter of 13 nm. The amphiphile aggregation was found to be dependent on exterior conditions such as solvent, dialysis, sonication, and temperature.

AB - Synthesis process of nanogel aggregates by an hydroxyl poly(amidoamine) amphiphiles containing rigid lipids in which the degree of hydrophobicity was controlled so they remained water soluble, is discussed. The amphiphilic cholesteryl-poly(amidoamine) dendrimer (Ch-G5OH) was prepared by conjugating cholesteryl chloroformate with generation five hydroxyl-terminated poly(amidoamine) dendrimer in the presence of triethylamine (Et3N) in a particular ratio of dendrimer hydroxyl groups to cholesteryl chloroformate. The amphiphile was found easily dissolvable in water, producing a clear aqueous solution with stable foams on shaking. TEM image of the Ch-G5OH amphiphile cast from a sonicated aqueous solution showed a globular aggregation with an average diameter of 13 nm. The amphiphile aggregation was found to be dependent on exterior conditions such as solvent, dialysis, sonication, and temperature.

KW - Amphiphiles

KW - Cholesteryl

KW - Dendrimers

KW - Hydrophobic interactions

KW - Nanogels

KW - Poly(amidoamine) dendrimer

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U2 - 10.1002/pola.21958

DO - 10.1002/pola.21958

M3 - Article

AN - SCOPUS:34250314503

SN - 0887-624X

VL - 45

SP - 2569

EP - 2575

JO - Journal of Polymer Science, Part A: Polymer Chemistry

JF - Journal of Polymer Science, Part A: Polymer Chemistry

IS - 12

ER -

Formation of nanogel aggregates by an amphiphilic cholesteryl- poly(amidoamine) dendrimer in aqueous media

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Keywords

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