Formation of 5′-amino-deoxy-dinucleoside monophosphates in the de-blocking of oligonucleotides via intermediate aryl phosphotriesters

J. F.M. de Rooij; P. M.J. Burgers; G. Wille-Hazeleger; J. H. Van Boom

doi:10.1093/nar/1.suppl_1.s37

Formation of 5′-amino-deoxy-dinucleoside monophosphates in the de-blocking of oligonucleotides via intermediate aryl phosphotriesters

J. F.M. de Rooij, P. M.J. Burgers, G. Wille-Hazeleger, J. H. Van Boom

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Ammonolysis of aryl groups from internucleotide linkages of oligonucleotides with a free 5′-hydroxy function leads to the formation of a considerable amount of side-products.

Original language	English
Pages (from-to)	s37-s42
Journal	Nucleic acids research
Volume	1
DOIs	https://doi.org/10.1093/nar/1.suppl_1.s37
State	Published - 1978

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@article{2de240690de24b269838fd83adcd63e5,

title = "Formation of 5′-amino-deoxy-dinucleoside monophosphates in the de-blocking of oligonucleotides via intermediate aryl phosphotriesters",

abstract = "Ammonolysis of aryl groups from internucleotide linkages of oligonucleotides with a free 5′-hydroxy function leads to the formation of a considerable amount of side-products.",

author = "{de Rooij}, {J. F.M.} and Burgers, {P. M.J.} and G. Wille-Hazeleger and {Van Boom}, {J. H.}",

year = "1978",

doi = "10.1093/nar/1.suppl_1.s37",

language = "English",

volume = "1",

pages = "s37--s42",

journal = "Nucleic Acids Research",

issn = "0305-1048",

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T1 - Formation of 5′-amino-deoxy-dinucleoside monophosphates in the de-blocking of oligonucleotides via intermediate aryl phosphotriesters

AU - de Rooij, J. F.M.

AU - Burgers, P. M.J.

AU - Wille-Hazeleger, G.

AU - Van Boom, J. H.

PY - 1978

Y1 - 1978

N2 - Ammonolysis of aryl groups from internucleotide linkages of oligonucleotides with a free 5′-hydroxy function leads to the formation of a considerable amount of side-products.

AB - Ammonolysis of aryl groups from internucleotide linkages of oligonucleotides with a free 5′-hydroxy function leads to the formation of a considerable amount of side-products.

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U2 - 10.1093/nar/1.suppl_1.s37

DO - 10.1093/nar/1.suppl_1.s37

M3 - Article

AN - SCOPUS:84914353392

VL - 1

SP - s37-s42

JO - Nucleic Acids Research

JF - Nucleic Acids Research

SN - 0305-1048

ER -

Formation of 5′-amino-deoxy-dinucleoside monophosphates in the de-blocking of oligonucleotides via intermediate aryl phosphotriesters

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