Formation of 5′-amino-deoxy-dinucleoside monophosphates in the de-blocking of oligonucleotides via intermediate aryl phosphotriesters

J. F.M. de Rooij, P. M.J. Burgers, G. Wille-Hazeleger, J. H. Van Boom

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Ammonolysis of aryl groups from internucleotide linkages of oligonucleotides with a free 5′-hydroxy function leads to the formation of a considerable amount of side-products.

Original languageEnglish
Pages (from-to)s37-s42
JournalNucleic acids research
Volume1
DOIs
StatePublished - Jan 1 1978
Externally publishedYes

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