TY - JOUR
T1 - Force and energy transmission at the brain-skull interface of the minipig in vivo and post-mortem
AU - Wang, Shuaihu
AU - Eckstein, Kevin N.
AU - Okamoto, Ruth J.
AU - McGarry, Matthew D.J.
AU - Johnson, Curtis L.
AU - Bayly, Philip V.
N1 - Publisher Copyright:
© 2024 Elsevier Ltd
PY - 2025/1
Y1 - 2025/1
N2 - The brain-skull interface plays an important role in the mechano-pathology of traumatic brain injury (TBI). A comprehensive understanding of the mechanical behavior of the brain-skull interface in vivo is significant for understanding the mechanisms of TBI and creating accurate computational models. Here we investigate the force and energy transmission at the minipig brain-skull interface by non-invasive methods in the live (in vivo) and dead animal (in situ). Displacement fields in the brain and skull were measured in four female minipigs by magnetic resonance elastography (MRE), and the relative displacements between the brain and skull were estimated. Surface maps of deviatoric stress, the apparent mechanical properties of the brain-skull interface, and the net energy flux were generated for each animal when alive and at specific times post-mortem. After death, these maps reveal increases in relative motion between brain and skull, brain surface stress, stiffness of brain-skull interface, and net energy flux from skull to brain. These results illustrate the ability to study both skull and brain mechanics by MRE; the observed post-mortem decrease in the protective capability of the brain-skull interface emphasizes the importance of measuring its behavior in vivo.
AB - The brain-skull interface plays an important role in the mechano-pathology of traumatic brain injury (TBI). A comprehensive understanding of the mechanical behavior of the brain-skull interface in vivo is significant for understanding the mechanisms of TBI and creating accurate computational models. Here we investigate the force and energy transmission at the minipig brain-skull interface by non-invasive methods in the live (in vivo) and dead animal (in situ). Displacement fields in the brain and skull were measured in four female minipigs by magnetic resonance elastography (MRE), and the relative displacements between the brain and skull were estimated. Surface maps of deviatoric stress, the apparent mechanical properties of the brain-skull interface, and the net energy flux were generated for each animal when alive and at specific times post-mortem. After death, these maps reveal increases in relative motion between brain and skull, brain surface stress, stiffness of brain-skull interface, and net energy flux from skull to brain. These results illustrate the ability to study both skull and brain mechanics by MRE; the observed post-mortem decrease in the protective capability of the brain-skull interface emphasizes the importance of measuring its behavior in vivo.
KW - Brain-skull interface
KW - Magnetic resonance elastography
KW - Post-mortem changes
KW - Traumatic brain injury
UR - http://www.scopus.com/inward/record.url?scp=85208194251&partnerID=8YFLogxK
U2 - 10.1016/j.jmbbm.2024.106775
DO - 10.1016/j.jmbbm.2024.106775
M3 - Article
C2 - 39515226
AN - SCOPUS:85208194251
SN - 1751-6161
VL - 161
JO - Journal of the Mechanical Behavior of Biomedical Materials
JF - Journal of the Mechanical Behavior of Biomedical Materials
M1 - 106775
ER -