Abstract
Massive perivillous fibrinoid deposition is a rare placental pathology associated with significant adverse pregnancy outcome and can recur. We provide a detailed case review of a woman through 10 of her pregnancies, including 8 consecutive pregnancy losses and 2 live births. We also conducted a retrospective chart review of all massive perivillous fibrinoid deposition placenta specimens at our institution over an eight-year period. A total of 42 cases of massive perivillous fibrinoid deposition were identified from 2007 to 2015, yielding an incidence of 0.16%. Recurrence was seen in subsequent pregnancy in eight out of nine (88.9%) cases with more than one specimen. The clinical characteristics, perinatal outcomes and α-feto protein level of the 42 cases are presented. Also, presented is a review of the literature discussing placental pathology, pathogenetic mechanisms and management of this condition.
Original language | English |
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Pages (from-to) | 17-22 |
Number of pages | 6 |
Journal | Obstetric Medicine |
Volume | 11 |
Issue number | 1 |
DOIs | |
State | Published - Mar 1 2018 |
Keywords
- Placenta
- massive perivillous fibrinoid deposition
- maternal floor infarction
- pregnancy loss