Follow-up and management of recurrent pregnancy losses due to massive perivillous fibrinoid deposition

Mai He, Alison Migliori, Nisreen S. Maari, Niharika D. Mehta

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Massive perivillous fibrinoid deposition is a rare placental pathology associated with significant adverse pregnancy outcome and can recur. We provide a detailed case review of a woman through 10 of her pregnancies, including 8 consecutive pregnancy losses and 2 live births. We also conducted a retrospective chart review of all massive perivillous fibrinoid deposition placenta specimens at our institution over an eight-year period. A total of 42 cases of massive perivillous fibrinoid deposition were identified from 2007 to 2015, yielding an incidence of 0.16%. Recurrence was seen in subsequent pregnancy in eight out of nine (88.9%) cases with more than one specimen. The clinical characteristics, perinatal outcomes and α-feto protein level of the 42 cases are presented. Also, presented is a review of the literature discussing placental pathology, pathogenetic mechanisms and management of this condition.

Original languageEnglish
Pages (from-to)17-22
Number of pages6
JournalObstetric Medicine
Volume11
Issue number1
DOIs
StatePublished - Mar 1 2018

Keywords

  • Placenta
  • massive perivillous fibrinoid deposition
  • maternal floor infarction
  • pregnancy loss

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