Focused Ultrasound Enabled Trans-Blood Brain Barrier Delivery of Gold Nanoclusters: Effect of Surface Charges and Quantification Using Positron Emission Tomography

Deborah Sultan, Dezhuang Ye, Gyu Seong Heo, Xiaohui Zhang, Hannah Luehmann, Yimei Yue, Lisa Detering, Sergey Komarov, Sara Taylor, Yuan Chuan Tai, Joshua B. Rubin, Hong Chen, Yongjian Liu

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Focused ultrasound (FUS) technology is reported to enhance the delivery of 64Cu-integrated ultrasmall gold nanoclusters (64Cu-AuNCs) across the blood-brain barrier (BBB) as measured by positron emission tomography (PET). To better define the optimal physical properties for brain delivery, 64Cu-AuNCs with different surface charges are synthesized and characterized. In vivo biodistribution studies are performed to compare the individual organ uptake of each type of 64Cu-AuNCs. Quantitative PET imaging post-FUS treatment shows site-targeted brain penetration, retention, and diffusion of the negative, neutral, and positive 64Cu-AuNCs. Autoradiography is performed to compare the intrabrain distribution of these nanoclusters. PET Imaging demonstrates the effective BBB opening and successful delivery of 64Cu-AuNCs into the brain. Of the three 64Cu-AuNCs investigated, the neutrally charged nanostructure performs the best and is the candidate platform for future theranostic applications in neuro-oncology.

Original languageEnglish
Article number1703115
JournalSmall
Volume14
Issue number30
DOIs
StatePublished - Jul 26 2018

Keywords

  • brain
  • focused ultrasound
  • imaging
  • nanoclusters
  • positron emission tomography

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