FN-C1q and C1 INH Clr-Cls complexes as indicators of complement activation in patients with chronic lymphocytic leukaemia

Tünde Hidvégi; Gennadi A. Ermolin; Evgeni E. Efremov; Michail M. Dikov; Ludmilla V. Kurmanova; Galina V. Vnashenkova; Marina V. Merkulova; Márta Kókai; Aranka Panya; George Füst

doi:10.1016/0165-2478(89)90133-8

FN-C1q and C1 INH Clr-Cls complexes as indicators of complement activation in patients with chronic lymphocytic leukaemia

Tünde Hidvégi, Gennadi A. Ermolin, Evgeni E. Efremov, Michail M. Dikov, Ludmilla V. Kurmanova, Galina V. Vnashenkova, Marina V. Merkulova, Márta Kókai, Aranka Panya, George Füst

Division of Gastroenterology, Hepatology & Nutrition

Research output: Contribution to journal › Article › peer-review

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Abstract

We have previously found low levels of C1 and C4 INH in the sera of chronic lymphocytic leukaemia (CLL) patients. Hypocomplementaemia was supposed to be the consequence of a permanent activation of the classical pathway. We have compared the levels of C1 INH-C1rC1s and C1q-FN complexes in the sera of 95 CLL patients and 100 healthy controls, because these complexes are known to be formed in the early stage of classical pathway activation. A significant increase in the level of both types of complexes was found in sera of CLL patients as compared to the controls. These findings support the assumption that the classical complement pathway is activated in the patients with CLL.

Original language	English
Pages (from-to)	1-6
Number of pages	6
Journal	Immunology Letters
Volume	22
Issue number	1
DOIs	https://doi.org/10.1016/0165-2478(89)90133-8
State	Published - Jul 1989

Keywords

C1 INH
C1rC1s
CLL
FN-C1q complexes
Hypocomplementaemia

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10.1016/0165-2478(89)90133-8

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@article{65c404859ba14456aa64d5280017c367,

title = "FN-C1q and C1 INH Clr-Cls complexes as indicators of complement activation in patients with chronic lymphocytic leukaemia",

abstract = "We have previously found low levels of C1 and C4 INH in the sera of chronic lymphocytic leukaemia (CLL) patients. Hypocomplementaemia was supposed to be the consequence of a permanent activation of the classical pathway. We have compared the levels of C1 INH-C1rC1s and C1q-FN complexes in the sera of 95 CLL patients and 100 healthy controls, because these complexes are known to be formed in the early stage of classical pathway activation. A significant increase in the level of both types of complexes was found in sera of CLL patients as compared to the controls. These findings support the assumption that the classical complement pathway is activated in the patients with CLL.",

keywords = "C1 INH, C1rC1s, CLL, FN-C1q complexes, Hypocomplementaemia",

author = "T{\"u}nde Hidv{\'e}gi and Ermolin, {Gennadi A.} and Efremov, {Evgeni E.} and Dikov, {Michail M.} and Kurmanova, {Ludmilla V.} and Vnashenkova, {Galina V.} and Merkulova, {Marina V.} and M{\'a}rta K{\'o}kai and Aranka Panya and George F{\"u}st",

year = "1989",

month = jul,

doi = "10.1016/0165-2478(89)90133-8",

language = "English",

volume = "22",

pages = "1--6",

journal = "Immunology Letters",

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TY - JOUR

T1 - FN-C1q and C1 INH Clr-Cls complexes as indicators of complement activation in patients with chronic lymphocytic leukaemia

AU - Hidvégi, Tünde

AU - Ermolin, Gennadi A.

AU - Efremov, Evgeni E.

AU - Dikov, Michail M.

AU - Kurmanova, Ludmilla V.

AU - Vnashenkova, Galina V.

AU - Merkulova, Marina V.

AU - Kókai, Márta

AU - Panya, Aranka

AU - Füst, George

PY - 1989/7

Y1 - 1989/7

N2 - We have previously found low levels of C1 and C4 INH in the sera of chronic lymphocytic leukaemia (CLL) patients. Hypocomplementaemia was supposed to be the consequence of a permanent activation of the classical pathway. We have compared the levels of C1 INH-C1rC1s and C1q-FN complexes in the sera of 95 CLL patients and 100 healthy controls, because these complexes are known to be formed in the early stage of classical pathway activation. A significant increase in the level of both types of complexes was found in sera of CLL patients as compared to the controls. These findings support the assumption that the classical complement pathway is activated in the patients with CLL.

AB - We have previously found low levels of C1 and C4 INH in the sera of chronic lymphocytic leukaemia (CLL) patients. Hypocomplementaemia was supposed to be the consequence of a permanent activation of the classical pathway. We have compared the levels of C1 INH-C1rC1s and C1q-FN complexes in the sera of 95 CLL patients and 100 healthy controls, because these complexes are known to be formed in the early stage of classical pathway activation. A significant increase in the level of both types of complexes was found in sera of CLL patients as compared to the controls. These findings support the assumption that the classical complement pathway is activated in the patients with CLL.

KW - C1 INH

KW - C1rC1s

KW - CLL

KW - FN-C1q complexes

KW - Hypocomplementaemia

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U2 - 10.1016/0165-2478(89)90133-8

DO - 10.1016/0165-2478(89)90133-8

M3 - Article

C2 - 2550362

AN - SCOPUS:0024356868

SN - 0165-2478

VL - 22

SP - 1

EP - 6

JO - Immunology Letters

JF - Immunology Letters

IS - 1

ER -

FN-C1q and C1 INH Clr-Cls complexes as indicators of complement activation in patients with chronic lymphocytic leukaemia

Abstract

Keywords

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