FMRFa-related endogenous peptides affect proton-activated currents in rat trigeminal neurons

O. Ostrovskaya; P. Lishko; A. Beketov; O. Krishtal

doi:10.1023/A:1020707517796

FMRFa-related endogenous peptides affect proton-activated currents in rat trigeminal neurons

O. Ostrovskaya
, P. Lishko
, A. Beketov
, O. Krishtal

Research output: Contribution to journal › Article › peer-review

Abstract

FLRFa, FIRFa, YMRFa, and some other peptides are found to slow down the kinetics of desensitization of proton-gated currents in rat trigeminal neurons but not in HEK-293T cell culture transfected with ASICα. The observed heterogeneity of peptide action in sensory neurons leads to a suggestion that FMRFa- related peptides may selectively affect transient current components of ASICβ and DRASIC/DRASIC-MDEG2 heteromers.

Original language	English
Pages (from-to)	194
Number of pages	1
Journal	Neurophysiology
Volume	34
Issue number	2-3
DOIs	https://doi.org/10.1023/A:1020707517796
State	Published - Mar 2002

Keywords

FMRFa-related peptides
Proton-gated currents
Trigeminal neurons

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10.1023/A:1020707517796

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title = "FMRFa-related endogenous peptides affect proton-activated currents in rat trigeminal neurons",

abstract = "FLRFa, FIRFa, YMRFa, and some other peptides are found to slow down the kinetics of desensitization of proton-gated currents in rat trigeminal neurons but not in HEK-293T cell culture transfected with ASICα. The observed heterogeneity of peptide action in sensory neurons leads to a suggestion that FMRFa- related peptides may selectively affect transient current components of ASICβ and DRASIC/DRASIC-MDEG2 heteromers.",

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author = "O. Ostrovskaya and P. Lishko and A. Beketov and O. Krishtal",

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AU - Ostrovskaya, O.

AU - Lishko, P.

AU - Beketov, A.

AU - Krishtal, O.

PY - 2002/3

Y1 - 2002/3

N2 - FLRFa, FIRFa, YMRFa, and some other peptides are found to slow down the kinetics of desensitization of proton-gated currents in rat trigeminal neurons but not in HEK-293T cell culture transfected with ASICα. The observed heterogeneity of peptide action in sensory neurons leads to a suggestion that FMRFa- related peptides may selectively affect transient current components of ASICβ and DRASIC/DRASIC-MDEG2 heteromers.

AB - FLRFa, FIRFa, YMRFa, and some other peptides are found to slow down the kinetics of desensitization of proton-gated currents in rat trigeminal neurons but not in HEK-293T cell culture transfected with ASICα. The observed heterogeneity of peptide action in sensory neurons leads to a suggestion that FMRFa- related peptides may selectively affect transient current components of ASICβ and DRASIC/DRASIC-MDEG2 heteromers.

KW - FMRFa-related peptides

KW - Proton-gated currents

KW - Trigeminal neurons

UR - https://www.scopus.com/pages/publications/0036524303

U2 - 10.1023/A:1020707517796

DO - 10.1023/A:1020707517796

M3 - Article

AN - SCOPUS:0036524303

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VL - 34

SP - 194

JO - Neurophysiology

JF - Neurophysiology

IS - 2-3

ER -

FMRFa-related endogenous peptides affect proton-activated currents in rat trigeminal neurons

Abstract

Keywords

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