Abstract
FLRFa, FIRFa, YMRFa, and some other peptides are found to slow down the kinetics of desensitization of proton-gated currents in rat trigeminal neurons but not in HEK-293T cell culture transfected with ASICα. The observed heterogeneity of peptide action in sensory neurons leads to a suggestion that FMRFa- related peptides may selectively affect transient current components of ASICβ and DRASIC/DRASIC-MDEG2 heteromers.
Original language | English |
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Pages (from-to) | 194 |
Number of pages | 1 |
Journal | Neurophysiology |
Volume | 34 |
Issue number | 2-3 |
DOIs | |
State | Published - Mar 2002 |
Keywords
- FMRFa-related peptides
- Proton-gated currents
- Trigeminal neurons