FMRFa-related endogenous peptides affect proton-activated currents in rat trigeminal neurons

O. Ostrovskaya, P. Lishko, A. Beketov, O. Krishtal

Research output: Contribution to journalArticlepeer-review

Abstract

FLRFa, FIRFa, YMRFa, and some other peptides are found to slow down the kinetics of desensitization of proton-gated currents in rat trigeminal neurons but not in HEK-293T cell culture transfected with ASICα. The observed heterogeneity of peptide action in sensory neurons leads to a suggestion that FMRFa- related peptides may selectively affect transient current components of ASICβ and DRASIC/DRASIC-MDEG2 heteromers.

Original languageEnglish
Pages (from-to)194
Number of pages1
JournalNeurophysiology
Volume34
Issue number2-3
DOIs
StatePublished - Mar 2002

Keywords

  • FMRFa-related peptides
  • Proton-gated currents
  • Trigeminal neurons

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