TY - JOUR
T1 - Flutamide-induced cyanosis refractory to methylene blue therapy
AU - Kouides, Peter A.
AU - Abboud, Camille N.
AU - Fairbanks, Virgil F.
PY - 1996/1/1
Y1 - 1996/1/1
N2 - Flutamide, an anti-androgen used in prostate cancer therapy, is also a derivative of aniline. Mild, usually asymptomatic, methaemoglobinaemia has been reported. We report a patient receiving flutamide therapy who developed cyanosis, dyspnoea and anaemia, initially attributed to marked methaemoglobinaemia by the CO-Oximeter method. An unsuccessful trial of methylene blue therapy led to the finding of marked sulphaemoglobinaemia. Sulphaemoglobinaemia has not previously been reported with flutamide use. Recognition of this association is important, given the refractoriness of sulphaemoglobinaemia to methylene blue therapy.
AB - Flutamide, an anti-androgen used in prostate cancer therapy, is also a derivative of aniline. Mild, usually asymptomatic, methaemoglobinaemia has been reported. We report a patient receiving flutamide therapy who developed cyanosis, dyspnoea and anaemia, initially attributed to marked methaemoglobinaemia by the CO-Oximeter method. An unsuccessful trial of methylene blue therapy led to the finding of marked sulphaemoglobinaemia. Sulphaemoglobinaemia has not previously been reported with flutamide use. Recognition of this association is important, given the refractoriness of sulphaemoglobinaemia to methylene blue therapy.
KW - Cyanosis
KW - Flutamide
KW - Methaemoglobinaemia
KW - Methylene blue
KW - Sulphaemoglobinaemia
UR - http://www.scopus.com/inward/record.url?scp=0030035714&partnerID=8YFLogxK
U2 - 10.1046/j.1365-2141.1996.d01-1766.x
DO - 10.1046/j.1365-2141.1996.d01-1766.x
M3 - Article
C2 - 8757511
AN - SCOPUS:0030035714
SN - 0007-1048
VL - 94
SP - 73
EP - 75
JO - British Journal of Haematology
JF - British Journal of Haematology
IS - 1
ER -