Fluorouracil Filtering Surgery Study One-Year Follow-up

W. L.M. Alward; Thomas Farrell; Sohan Hayreh; Hansjoerg Kolder; Bernita Carney; Michael Gressel; John Costin; Paul Craven; Michael Zgrabik; Barbara Simashkevich; Pamela Schremp; Dale K. Heuer; George Baerveldt; Don Minckler; James Martone; John Irvine; Peter Liggett; Alfredo Sadun; Ronald Green; John Lean; Peter Mcdonnell; Frances Walonker; Eva Griffay; Andrea Miller-Scholte; Michael Kass; Allan Kolker; Martha Farber; Lawrence Gans; Morton Smith; Arnold Jones; Shirley Klenke; Alyson Owensby; K. Parrish Richard; Elizabeth Hodapp; Paul F. Palmberg; Douglas R. Anderson; Yasmina Rosario; Madeline Del Calvo; Marilyn Mule; Ann Carter; Ana Fajardo; Mark Sherwood; George Stern; William Driebe; John Guy; Marwa Adi; Maher Fanous; Diana Shamis; Past Dale K. Heuer; Harry Engel; Jacob Wilensky; Eve Higginbotham; Howard Tessler; Diane Frohlichstein; Robert Barnes; Sao Liu; Richard L. Mowery; Anita Suran; Israel Goldberg; Peter Dudley; Joyce Schiffman; Ross Schwelm; William Feuer; Dennis Gillings; Luz Gual; Patricia Anderson; Curt Furberg; David Dueker; Sylvan B. Green; Alan M. Laties; Katherine E. Peres; Robert F. Taylor; M. Christina Leske; Donald Enkerud; Antonio Cubillas; Ross Jarrett

doi:10.1016/j.ajo.2017.12.021

Fluorouracil Filtering Surgery Study One-Year Follow-up

W. L.M. Alward, Thomas Farrell, Sohan Hayreh, Hansjoerg Kolder, Bernita Carney, Michael Gressel, John Costin, Paul Craven, Michael Zgrabik, Barbara Simashkevich, Pamela Schremp, Dale K. Heuer, George Baerveldt, Don Minckler, James Martone, John Irvine, Peter Liggett, Alfredo Sadun, Ronald Green, John LeanPeter Mcdonnell, Frances Walonker, Eva Griffay, Andrea Miller-Scholte, Michael Kass, Allan Kolker, Martha Farber, Lawrence Gans, Morton Smith, Arnold Jones, Shirley Klenke, Alyson Owensby, K. Parrish Richard, Elizabeth Hodapp, Paul F. Palmberg, Douglas R. Anderson, Yasmina Rosario, Madeline Del Calvo, Marilyn Mule, Ann Carter, Ana Fajardo, Mark Sherwood, George Stern, William Driebe, John Guy, Marwa Adi, Maher Fanous, Diana Shamis, Past Dale K. Heuer, Harry Engel, Jacob Wilensky, Eve Higginbotham, Howard Tessler, Diane Frohlichstein, Robert Barnes, Sao Liu, Richard L. Mowery, Anita Suran, Israel Goldberg, Peter Dudley, Joyce Schiffman, Ross Schwelm, William Feuer, Dennis Gillings, Luz Gual, Patricia Anderson, Curt Furberg, David Dueker, Sylvan B. Green, Alan M. Laties, Katherine E. Peres, Robert F. Taylor, M. Christina Leske, Donald Enkerud, Antonio Cubillas, Ross Jarrett

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Two hundred thirteen patients participated in the Fluorouracil Filtering Surgery Study, a randomized clinical trial, to determine the efficacy and safety of subconjunctivally injected 5-fluorouracil after filtering surgery in eyes with poor prognoses. Twenty-eight (27%) of the 105 eyes in the 5-fluorouracil group and 54 (50%) of the 108 eyes in the standard group were classified as failures, defined by reoperation for control of intraocular pressure during the first year or an intraocular pressure greater than 21 mm Hg at the one-year visit (P =.0007, Mantel-Haenszel chi-square). Corneal epithelial toxicity and transient visual acuity loss were more common in the 5-fluorouracil group (P <.001, chi-square); however, the visual acuities and the mean visual field sensitivities were not significantly different at one year. We recommend the use of subconjunctivally injected 5-fluorouracil after trabeculectomy in eyes with uncontrolled glaucoma and poor prognoses, specifically after previous cataract extraction or unsuccessful filtering surgery.

Original language	English
Pages (from-to)	xxxiii-xlii
Journal	American journal of ophthalmology
Volume	186
DOIs	https://doi.org/10.1016/j.ajo.2017.12.021
State	Published - Feb 2018

Access to Document

10.1016/j.ajo.2017.12.021

Cite this

Alward, W. L. M., Farrell, T., Hayreh, S., Kolder, H., Carney, B., Gressel, M., Costin, J., Craven, P., Zgrabik, M., Simashkevich, B., Schremp, P., Heuer, D. K., Baerveldt, G., Minckler, D., Martone, J., Irvine, J., Liggett, P., Sadun, A., Green, R., ... Jarrett, R. (2018). Fluorouracil Filtering Surgery Study One-Year Follow-up. American journal of ophthalmology, 186, xxxiii-xlii. https://doi.org/10.1016/j.ajo.2017.12.021

@article{1f210a8ecb544d2fa1cecffc9f0493c2,

title = "Fluorouracil Filtering Surgery Study One-Year Follow-up",

abstract = "Two hundred thirteen patients participated in the Fluorouracil Filtering Surgery Study, a randomized clinical trial, to determine the efficacy and safety of subconjunctivally injected 5-fluorouracil after filtering surgery in eyes with poor prognoses. Twenty-eight (27%) of the 105 eyes in the 5-fluorouracil group and 54 (50%) of the 108 eyes in the standard group were classified as failures, defined by reoperation for control of intraocular pressure during the first year or an intraocular pressure greater than 21 mm Hg at the one-year visit (P =.0007, Mantel-Haenszel chi-square). Corneal epithelial toxicity and transient visual acuity loss were more common in the 5-fluorouracil group (P <.001, chi-square); however, the visual acuities and the mean visual field sensitivities were not significantly different at one year. We recommend the use of subconjunctivally injected 5-fluorouracil after trabeculectomy in eyes with uncontrolled glaucoma and poor prognoses, specifically after previous cataract extraction or unsuccessful filtering surgery.",

author = "Alward, {W. L.M.} and Thomas Farrell and Sohan Hayreh and Hansjoerg Kolder and Bernita Carney and Michael Gressel and John Costin and Paul Craven and Michael Zgrabik and Barbara Simashkevich and Pamela Schremp and Heuer, {Dale K.} and George Baerveldt and Don Minckler and James Martone and John Irvine and Peter Liggett and Alfredo Sadun and Ronald Green and John Lean and Peter Mcdonnell and Frances Walonker and Eva Griffay and Andrea Miller-Scholte and Michael Kass and Allan Kolker and Martha Farber and Lawrence Gans and Morton Smith and Arnold Jones and Shirley Klenke and Alyson Owensby and Richard, {K. Parrish} and Elizabeth Hodapp and Palmberg, {Paul F.} and Anderson, {Douglas R.} and Yasmina Rosario and Calvo, {Madeline Del} and Marilyn Mule and Ann Carter and Ana Fajardo and Mark Sherwood and George Stern and William Driebe and John Guy and Marwa Adi and Maher Fanous and Diana Shamis and Heuer, {Past Dale K.} and Harry Engel and Jacob Wilensky and Eve Higginbotham and Howard Tessler and Diane Frohlichstein and Robert Barnes and Sao Liu and Mowery, {Richard L.} and Anita Suran and Israel Goldberg and Peter Dudley and Joyce Schiffman and Ross Schwelm and William Feuer and Dennis Gillings and Luz Gual and Patricia Anderson and Curt Furberg and David Dueker and Green, {Sylvan B.} and Laties, {Alan M.} and Peres, {Katherine E.} and Taylor, {Robert F.} and Leske, {M. Christina} and Donald Enkerud and Antonio Cubillas and Ross Jarrett",

note = "Publisher Copyright: {\textcopyright} 2017 Elsevier Inc.",

year = "2018",

month = feb,

doi = "10.1016/j.ajo.2017.12.021",

language = "English",

volume = "186",

pages = "xxxiii--xlii",

journal = "American journal of ophthalmology",

issn = "0002-9394",

}

Alward, WLM, Farrell, T, Hayreh, S, Kolder, H, Carney, B, Gressel, M, Costin, J, Craven, P, Zgrabik, M, Simashkevich, B, Schremp, P, Heuer, DK, Baerveldt, G, Minckler, D, Martone, J, Irvine, J, Liggett, P, Sadun, A, Green, R, Lean, J, Mcdonnell, P, Walonker, F, Griffay, E, Miller-Scholte, A, Kass, M, Kolker, A, Farber, M, Gans, L, Smith, M, Jones, A, Klenke, S, Owensby, A, Richard, KP, Hodapp, E, Palmberg, PF, Anderson, DR, Rosario, Y, Calvo, MD, Mule, M, Carter, A, Fajardo, A, Sherwood, M, Stern, G, Driebe, W, Guy, J, Adi, M, Fanous, M, Shamis, D, Heuer, PDK, Engel, H, Wilensky, J, Higginbotham, E, Tessler, H, Frohlichstein, D, Barnes, R, Liu, S, Mowery, RL, Suran, A, Goldberg, I, Dudley, P, Schiffman, J, Schwelm, R, Feuer, W, Gillings, D, Gual, L, Anderson, P, Furberg, C, Dueker, D, Green, SB, Laties, AM, Peres, KE, Taylor, RF, Leske, MC, Enkerud, D, Cubillas, A & Jarrett, R 2018, 'Fluorouracil Filtering Surgery Study One-Year Follow-up', American journal of ophthalmology, vol. 186, pp. xxxiii-xlii. https://doi.org/10.1016/j.ajo.2017.12.021

TY - JOUR

T1 - Fluorouracil Filtering Surgery Study One-Year Follow-up

AU - Alward, W. L.M.

AU - Farrell, Thomas

AU - Hayreh, Sohan

AU - Kolder, Hansjoerg

AU - Carney, Bernita

AU - Gressel, Michael

AU - Costin, John

AU - Craven, Paul

AU - Zgrabik, Michael

AU - Simashkevich, Barbara

AU - Schremp, Pamela

AU - Heuer, Dale K.

AU - Baerveldt, George

AU - Minckler, Don

AU - Martone, James

AU - Irvine, John

AU - Liggett, Peter

AU - Sadun, Alfredo

AU - Green, Ronald

AU - Lean, John

AU - Mcdonnell, Peter

AU - Walonker, Frances

AU - Griffay, Eva

AU - Miller-Scholte, Andrea

AU - Kass, Michael

AU - Kolker, Allan

AU - Farber, Martha

AU - Gans, Lawrence

AU - Smith, Morton

AU - Jones, Arnold

AU - Klenke, Shirley

AU - Owensby, Alyson

AU - Richard, K. Parrish

AU - Hodapp, Elizabeth

AU - Palmberg, Paul F.

AU - Anderson, Douglas R.

AU - Rosario, Yasmina

AU - Calvo, Madeline Del

AU - Mule, Marilyn

AU - Carter, Ann

AU - Fajardo, Ana

AU - Sherwood, Mark

AU - Stern, George

AU - Driebe, William

AU - Guy, John

AU - Adi, Marwa

AU - Fanous, Maher

AU - Shamis, Diana

AU - Heuer, Past Dale K.

AU - Engel, Harry

AU - Wilensky, Jacob

AU - Higginbotham, Eve

AU - Tessler, Howard

AU - Frohlichstein, Diane

AU - Barnes, Robert

AU - Liu, Sao

AU - Mowery, Richard L.

AU - Suran, Anita

AU - Goldberg, Israel

AU - Dudley, Peter

AU - Schiffman, Joyce

AU - Schwelm, Ross

AU - Feuer, William

AU - Gillings, Dennis

AU - Gual, Luz

AU - Anderson, Patricia

AU - Furberg, Curt

AU - Dueker, David

AU - Green, Sylvan B.

AU - Laties, Alan M.

AU - Peres, Katherine E.

AU - Taylor, Robert F.

AU - Leske, M. Christina

AU - Enkerud, Donald

AU - Cubillas, Antonio

AU - Jarrett, Ross

PY - 2018/2

Y1 - 2018/2

N2 - Two hundred thirteen patients participated in the Fluorouracil Filtering Surgery Study, a randomized clinical trial, to determine the efficacy and safety of subconjunctivally injected 5-fluorouracil after filtering surgery in eyes with poor prognoses. Twenty-eight (27%) of the 105 eyes in the 5-fluorouracil group and 54 (50%) of the 108 eyes in the standard group were classified as failures, defined by reoperation for control of intraocular pressure during the first year or an intraocular pressure greater than 21 mm Hg at the one-year visit (P =.0007, Mantel-Haenszel chi-square). Corneal epithelial toxicity and transient visual acuity loss were more common in the 5-fluorouracil group (P <.001, chi-square); however, the visual acuities and the mean visual field sensitivities were not significantly different at one year. We recommend the use of subconjunctivally injected 5-fluorouracil after trabeculectomy in eyes with uncontrolled glaucoma and poor prognoses, specifically after previous cataract extraction or unsuccessful filtering surgery.

AB - Two hundred thirteen patients participated in the Fluorouracil Filtering Surgery Study, a randomized clinical trial, to determine the efficacy and safety of subconjunctivally injected 5-fluorouracil after filtering surgery in eyes with poor prognoses. Twenty-eight (27%) of the 105 eyes in the 5-fluorouracil group and 54 (50%) of the 108 eyes in the standard group were classified as failures, defined by reoperation for control of intraocular pressure during the first year or an intraocular pressure greater than 21 mm Hg at the one-year visit (P =.0007, Mantel-Haenszel chi-square). Corneal epithelial toxicity and transient visual acuity loss were more common in the 5-fluorouracil group (P <.001, chi-square); however, the visual acuities and the mean visual field sensitivities were not significantly different at one year. We recommend the use of subconjunctivally injected 5-fluorouracil after trabeculectomy in eyes with uncontrolled glaucoma and poor prognoses, specifically after previous cataract extraction or unsuccessful filtering surgery.

UR - http://www.scopus.com/inward/record.url?scp=85057009063&partnerID=8YFLogxK

U2 - 10.1016/j.ajo.2017.12.021

DO - 10.1016/j.ajo.2017.12.021

M3 - Article

C2 - 29420951

AN - SCOPUS:85057009063

SN - 0002-9394

VL - 186

SP - xxxiii-xlii

JO - American journal of ophthalmology

JF - American journal of ophthalmology

ER -

Fluorouracil Filtering Surgery Study One-Year Follow-up

Abstract

Access to Document

Other files and links

Fingerprint

Cite this