Fluorescence Correlation Spectroscopy and Phase Separation

Juan Jeremías Incicco, Debjit Roy, Melissa D. Stuchell-Brereton, Andrea Soranno

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

A quantitative understanding of the forces controlling the assembly and functioning of biomolecular condensates requires the identification of phase boundaries at which condensates form as well as the determination of tie-lines. Here, we describe in detail how Fluorescence Correlation Spectroscopy (FCS) provides a versatile approach to estimate phase boundaries of single-component and multicomponent solutions as well as insights about the transport properties of the condensate.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages161-198
Number of pages38
DOIs
StatePublished - 2023

Publication series

NameMethods in Molecular Biology
Volume2563
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029

Keywords

  • Biomolecular condensates
  • Fluorescence Correlation Spectroscopy
  • Intrinsically disordered proteins
  • Phase separation

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