Fluid dynamics of a novel micro-fistula implant for the surgical treatment of glaucoma

Arsham Sheybani, Herbert Reitsamer, Iqbal Ike K. Ahmed

Research output: Contribution to journalArticlepeer-review

145 Scopus citations


PURPOSE. The purpose of this study was to describe the fluidics of a novel non-valved glaucoma implant designed to prevent hypotony and compare the fluidics of this device with two commonly used non-valved glaucoma devices. METHODS. The XEN 45 micro-fistula implant was designed to limit hypotony by virtue of its length and width according to the Hagen-Poiseuille equation. Flow testing was performed using a syringe pump and pressure transducer at multiple flow rates. The pressure differentials across the XEN implant, the Ex-Press implant, and 10 mm of silicone tubing from a Baerveldt implant at a physiologic flow rate (2.5 µL/min) were extrapolated. RESULTS. The XEN 45 achieved a steady-state pressure calculated at 7.56 mm Hg at 2.5 µL/min. At the same flow rate, the Ex-Press device and Baerveldt tubing reached steady-state pressures of 0.09 and 0.01 mm Hg, respectively. CONCLUSIONS. Under flow testing, the XEN micro-fistula implant was able to maintain backpressure above numerical hypotony levels without the use of complex valve systems. This is due to the XEN implant’s design, derived from the principles that dictate Newtonian fluids.

Original languageEnglish
Pages (from-to)4789-4795
Number of pages7
JournalInvestigative Ophthalmology and Visual Science
Issue number8
StatePublished - 2015


  • Fluidics
  • Glaucoma surgery
  • MIGS


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