Flow cytometry derived DNA content of the primary lesions of advanced germ cell tumours

G. W. Sledge; J. N. Eble; B. J. Roth; B. P. Wuhrman; L. H. Einhorn

doi:10.1111/j.1365-2605.1987.tb00172.x

Flow cytometry derived DNA content of the primary lesions of advanced germ cell tumours

G. W. Sledge, J. N. Eble, B. J. Roth, B. P. Wuhrman, L. H. Einhorn

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Abstract

We currently lack good prognostic indicators for patients with advanced disseminated germ cell tumours (GCT). An analysis of archival tumour samples of forty-nine patients with advanced GCT for flow cytometry derived DNA content suggests an inverse relationship between tumour proliferative activity and patient survival. The great majority of patients with advanced GCT have aneuploid tumour subpopulation. This analysis suggests that the survival of patients with advanced GCT may depend in part on kinetic variables present in the primary tumour.

Original language	English
Pages (from-to)	115-120
Number of pages	6
Journal	International Journal of Andrology
Volume	10
Issue number	1 SPEC.
DOIs	https://doi.org/10.1111/j.1365-2605.1987.tb00172.x
State	Published - 1987

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abstract = "We currently lack good prognostic indicators for patients with advanced disseminated germ cell tumours (GCT). An analysis of archival tumour samples of forty-nine patients with advanced GCT for flow cytometry derived DNA content suggests an inverse relationship between tumour proliferative activity and patient survival. The great majority of patients with advanced GCT have aneuploid tumour subpopulation. This analysis suggests that the survival of patients with advanced GCT may depend in part on kinetic variables present in the primary tumour.",

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AU - Eble, J. N.

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AU - Einhorn, L. H.

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AB - We currently lack good prognostic indicators for patients with advanced disseminated germ cell tumours (GCT). An analysis of archival tumour samples of forty-nine patients with advanced GCT for flow cytometry derived DNA content suggests an inverse relationship between tumour proliferative activity and patient survival. The great majority of patients with advanced GCT have aneuploid tumour subpopulation. This analysis suggests that the survival of patients with advanced GCT may depend in part on kinetic variables present in the primary tumour.

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Flow cytometry derived DNA content of the primary lesions of advanced germ cell tumours

Abstract

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