@article{490c3919ab974d0688b3e201676d461e,
title = "Flortaucipir (tau) PET in LGI1 antibody encephalitis",
abstract = "The contributors to persistent cognitive impairment and hippocampal atrophy in leucine-rich glioma-inactivated 1 antibody encephalitis (LGI1) patients are unknown. We evaluated whether tau neuropathology measured with [18F]flortaucipir PET neuroimaging associated with persistent cognitive impairment and hippocampal atrophy in four recovering LGI1 patients (3 men; median age, 67 [37–88] years). Imaging findings in cases were compared with those observed in age- and gender-similar cognitively normal individuals (n = 124) and individuals with early-symptomatic Alzheimer disease (n = 11). Elevated [18F]flortaucipir retention was observed in the two LGI1 patients with hippocampal atrophy and persistent cognitive impairment, including one with autopsy-confirmed Alzheimer disease. Tau neuropathology may associate with cognitive complaints and hippocampal atrophy in recovering LGI1 patients.",
author = "Gregory Day and Gordon, {Brian A.} and Austin McCullough and Bucelli, {Robert C.} and Perrin, {Richard J.} and Benzinger, {Tammie L.S.} and Ances, {Beau M.}",
note = "Funding Information: This study was supported by grants from the National Institutes of Health (K23AG064029, K01AG053474, P50AG005681, P01AG003991, P01AG026276, R01AG057680, R01AG052550, the Paula and Roger O. Riney Fund, the Daniel J Brennan Fund (BMA), and patient‐directed donations (GSD). [F]Flortaucipir precursor and technology were supported by AVID Radiopharmaceuticals. The funding organization did not contribute to the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication. 18 Funding Information: This study was supported by grants from the National Institutes of Health (K23AG064029, K01AG053474, P50AG005681, P01AG003991, P01AG026276, R01AG057680, R01AG052550, the Paula and Roger O. Riney Fund, the Daniel J Brennan Fund (BMA), and patient‐directed donations (GSD). Publisher Copyright: {\textcopyright} 2021 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.",
year = "2021",
month = feb,
doi = "10.1002/acn3.51297",
language = "English",
volume = "8",
pages = "491--497",
journal = "Annals of Clinical and Translational Neurology",
issn = "2328-9503",
number = "2",
}