Flecainide and amiodarone interaction

Patrick Shea, Roop Lal, Sung Soon Kim, Kenneth Schechtman, Rodolphe Ruffy

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53 Scopus citations


Oral amiodarone therapy was given to seven patients already taking oral flecainide regularly. In one additional patient, administration of flecainide was temporarily discontinued when amiodarone therapy was begun, and then resumed. Amiodarone produced a rise in mean dose-adjusted flecainide plasma level (trough plasma level at steady state/daily dose) from 2.3 ± 0.8 to 3.4 ± 0.9 (ng/ml)/(mg/day) (p < 0.01). Accordingly, the mean dose of flecainide required to maintain similar plasma levels of the drug was one-third lower during combined treatment than during therapy with flecainide alone. This drug interaction must be accounted for when amiodarone and flecainide are used concomitantly.

Original languageEnglish
Pages (from-to)1127-1130
Number of pages4
JournalJournal of the American College of Cardiology
Issue number5
StatePublished - 1986


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