Flavonoid effects on normal and leukemic cells

Jane L. Liesveld; Camille N. Abboud; Chaohui Lu; Curtiss McNair; Aarti Menon; Alan Smith; Karen Rosell; Aaron P. Rapoport

doi:10.1016/S0145-2126(02)00265-5

Flavonoid effects on normal and leukemic cells

Jane L. Liesveld, Camille N. Abboud, Chaohui Lu, Curtiss McNair, Aarti Menon, Alan Smith, Karen Rosell, Aaron P. Rapoport

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57 Scopus citations

Abstract

Quercetin and flavopiridol, both flavonoids which influence oxidative milieu, proliferation, and apoptosis of various cell types, were examined for their effects on acute myelogenous leukemic cells and normal progenitors. Both quercetin and flavopiridol inhibited the growth and viability of various acute myelogenous leukemia (AML) cell lines and AML blasts isolated afresh from patients with AML of various subtypes. The effects on inhibition of proliferation and decreased viability were also significant in normal CD34+ cells isolated from normal marrow donors. In certain AML cases, the effects of flavopiridol appeared to be mediated through activation of caspase 3, offering one possible mechanism for the apoptosis evident after exposure to flavopiridol as measured by annexin V expression. These flavonoid compounds might find use in various therapeutic settings in AML.

Original language	English
Pages (from-to)	517-527
Number of pages	11
Journal	Leukemia Research
Volume	27
Issue number	6
DOIs	https://doi.org/10.1016/S0145-2126(02)00265-5
State	Published - Jun 1 2003

Keywords

Apoptosis
Caspase 3
Flavopiridol
Proliferation
Quercetin

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10.1016/S0145-2126(02)00265-5

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title = "Flavonoid effects on normal and leukemic cells",

abstract = "Quercetin and flavopiridol, both flavonoids which influence oxidative milieu, proliferation, and apoptosis of various cell types, were examined for their effects on acute myelogenous leukemic cells and normal progenitors. Both quercetin and flavopiridol inhibited the growth and viability of various acute myelogenous leukemia (AML) cell lines and AML blasts isolated afresh from patients with AML of various subtypes. The effects on inhibition of proliferation and decreased viability were also significant in normal CD34+ cells isolated from normal marrow donors. In certain AML cases, the effects of flavopiridol appeared to be mediated through activation of caspase 3, offering one possible mechanism for the apoptosis evident after exposure to flavopiridol as measured by annexin V expression. These flavonoid compounds might find use in various therapeutic settings in AML.",

keywords = "Apoptosis, Caspase 3, Flavopiridol, Proliferation, Quercetin",

author = "Liesveld, {Jane L.} and Abboud, {Camille N.} and Chaohui Lu and Curtiss McNair and Aarti Menon and Alan Smith and Karen Rosell and Rapoport, {Aaron P.}",

note = "Funding Information: Supported by ACS grant DHP-173. JLL is a Clinical Scholar of the Leukemia and Lymphoma Society of America. ",

year = "2003",

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doi = "10.1016/S0145-2126(02)00265-5",

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T1 - Flavonoid effects on normal and leukemic cells

AU - Liesveld, Jane L.

AU - Abboud, Camille N.

AU - Lu, Chaohui

AU - McNair, Curtiss

AU - Menon, Aarti

AU - Smith, Alan

AU - Rosell, Karen

AU - Rapoport, Aaron P.

N1 - Funding Information: Supported by ACS grant DHP-173. JLL is a Clinical Scholar of the Leukemia and Lymphoma Society of America.

PY - 2003/6/1

Y1 - 2003/6/1

N2 - Quercetin and flavopiridol, both flavonoids which influence oxidative milieu, proliferation, and apoptosis of various cell types, were examined for their effects on acute myelogenous leukemic cells and normal progenitors. Both quercetin and flavopiridol inhibited the growth and viability of various acute myelogenous leukemia (AML) cell lines and AML blasts isolated afresh from patients with AML of various subtypes. The effects on inhibition of proliferation and decreased viability were also significant in normal CD34+ cells isolated from normal marrow donors. In certain AML cases, the effects of flavopiridol appeared to be mediated through activation of caspase 3, offering one possible mechanism for the apoptosis evident after exposure to flavopiridol as measured by annexin V expression. These flavonoid compounds might find use in various therapeutic settings in AML.

AB - Quercetin and flavopiridol, both flavonoids which influence oxidative milieu, proliferation, and apoptosis of various cell types, were examined for their effects on acute myelogenous leukemic cells and normal progenitors. Both quercetin and flavopiridol inhibited the growth and viability of various acute myelogenous leukemia (AML) cell lines and AML blasts isolated afresh from patients with AML of various subtypes. The effects on inhibition of proliferation and decreased viability were also significant in normal CD34+ cells isolated from normal marrow donors. In certain AML cases, the effects of flavopiridol appeared to be mediated through activation of caspase 3, offering one possible mechanism for the apoptosis evident after exposure to flavopiridol as measured by annexin V expression. These flavonoid compounds might find use in various therapeutic settings in AML.

KW - Apoptosis

KW - Caspase 3

KW - Flavopiridol

KW - Proliferation

KW - Quercetin

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U2 - 10.1016/S0145-2126(02)00265-5

DO - 10.1016/S0145-2126(02)00265-5

M3 - Article

C2 - 12648512

AN - SCOPUS:0037409044

SN - 0145-2126

VL - 27

SP - 517

EP - 527

JO - Leukemia Research

JF - Leukemia Research

IS - 6

ER -

Flavonoid effects on normal and leukemic cells

Abstract

Keywords

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