TY - JOUR
T1 - Five-year outcomes of premature infants randomized to high or standard loading dose caffeine
AU - McPherson, Christopher
AU - Lean, Rachel E.
AU - Cyr, Peppar E.P.
AU - Inder, Terrie E.
AU - Rogers, Cynthia E.
AU - Smyser, Christopher D.
N1 - Funding Information:
Support by the National Institute of Health (R01 HD057098 to TEI; R01 MH113570 to CER and CDS; F30 HD105336 to PEPC; K01 MH122735 to REL; K02 NS089852 to CDS; K12 HD055931-06; K23 MH105179 to CER), the Intellectual and Developmental Disabilities Research Center at Washington University (NIH/NICHD P50 HD103525), and the Doris Duke Charitable Foundation.
Funding Information:
We thank past and current members of the Washington University Neonatal Developmental Research group (particularly Jessica Perkins, Rachel Paul, Tara Smyser, and Karen Lob for follow-up study coordination and data collection), the Washington University Intellectual and Developmental Disabilities Research Center for assistance with data collection, and the children and families involved with the study.
Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer Nature America, Inc.
PY - 2022/5
Y1 - 2022/5
N2 - Objective: To examine 5-year outcomes in children enrolled in a pilot randomized controlled trial of a high loading dose of caffeine after preterm birth. Study design: Seventy-four very low birth weight neonates were randomized within the first 24 h of life to receive a high (80 mg/kg) or standard (20 mg/kg) loading dose of caffeine citrate. At 5 years of age, we conducted standardized neurodevelopmental tests and collected parent reports of child socioemotional problems. Result: Seventy-four percent of survivors returned for follow up. Children obtained similar scores on neurodevelopmental and socioemotional evaluations. There was no difference in the incidence of any neurodevelopmental delay after controlling for confounding factors. Conclusion: Five-year follow up of a pilot trial of high loading dose caffeine citrate documented no profound impacts on childhood neurodevelopment or socioemotional outcome.
AB - Objective: To examine 5-year outcomes in children enrolled in a pilot randomized controlled trial of a high loading dose of caffeine after preterm birth. Study design: Seventy-four very low birth weight neonates were randomized within the first 24 h of life to receive a high (80 mg/kg) or standard (20 mg/kg) loading dose of caffeine citrate. At 5 years of age, we conducted standardized neurodevelopmental tests and collected parent reports of child socioemotional problems. Result: Seventy-four percent of survivors returned for follow up. Children obtained similar scores on neurodevelopmental and socioemotional evaluations. There was no difference in the incidence of any neurodevelopmental delay after controlling for confounding factors. Conclusion: Five-year follow up of a pilot trial of high loading dose caffeine citrate documented no profound impacts on childhood neurodevelopment or socioemotional outcome.
UR - http://www.scopus.com/inward/record.url?scp=85124556080&partnerID=8YFLogxK
U2 - 10.1038/s41372-022-01333-5
DO - 10.1038/s41372-022-01333-5
M3 - Article
C2 - 35145209
AN - SCOPUS:85124556080
SN - 0743-8346
VL - 42
SP - 631
EP - 635
JO - Journal of Perinatology
JF - Journal of Perinatology
IS - 5
ER -