TY - JOUR
T1 - First-phase insulin release during the intravenous glucose tolerance test as a risk factor for type 1 diabetes
AU - Chase, H. Peter
AU - Cuthbertson, David D.
AU - Dolan, Lawrence M.
AU - Kaufman, Francine
AU - Krischer, Jeffrey P.
AU - Schatz, Desmond A.
AU - White, Neil H.
AU - Wilson, Darrell M.
AU - Wolfsdorf, Joseph
PY - 2001
Y1 - 2001
N2 - Objective: To determine the relationship between first-phase (1 minute + 3 minutes) insulin production during the intravenous glucose tolerance test (IV-GTT) and risk factors for developing type 1 diabetes. Study design: Relatives of persons with type 1 diabetes (n = 59,600) were screened for islet cell antibodies (ICAs). Subjects who had positive screening results underwent IV-GTT (≥2 times), repeat ICA screening, insulin autoantibody (IAA) screening twice, and an oral glucose tolerance test. Results: Of the 59,600 subjects in the study, 2199 (3.69%) had positive findings on initial ICA test. IV-GTTs were performed in 1622 subjects, with children <8 years having the lowest first-phase insulin release (FPIR) and subjects 8 to 20 years of age having the highest FPIR. The FPIR was lower for subjects with a confirmed positive ICA test result or a positive IAA test result, subjects with higher titers of ICA or IAA, and subjects who had an abnormal (impaired or diabetic) oral glucose tolerance test result. Conclusion: FPIR in the IV-GTT correlates strongly with risk factors for development of type 1 diabetes.
AB - Objective: To determine the relationship between first-phase (1 minute + 3 minutes) insulin production during the intravenous glucose tolerance test (IV-GTT) and risk factors for developing type 1 diabetes. Study design: Relatives of persons with type 1 diabetes (n = 59,600) were screened for islet cell antibodies (ICAs). Subjects who had positive screening results underwent IV-GTT (≥2 times), repeat ICA screening, insulin autoantibody (IAA) screening twice, and an oral glucose tolerance test. Results: Of the 59,600 subjects in the study, 2199 (3.69%) had positive findings on initial ICA test. IV-GTTs were performed in 1622 subjects, with children <8 years having the lowest first-phase insulin release (FPIR) and subjects 8 to 20 years of age having the highest FPIR. The FPIR was lower for subjects with a confirmed positive ICA test result or a positive IAA test result, subjects with higher titers of ICA or IAA, and subjects who had an abnormal (impaired or diabetic) oral glucose tolerance test result. Conclusion: FPIR in the IV-GTT correlates strongly with risk factors for development of type 1 diabetes.
UR - http://www.scopus.com/inward/record.url?scp=0035131854&partnerID=8YFLogxK
U2 - 10.1067/mpd.2001.111274
DO - 10.1067/mpd.2001.111274
M3 - Article
C2 - 11174623
AN - SCOPUS:0035131854
SN - 0022-3476
VL - 138
SP - 244
EP - 249
JO - Journal of Pediatrics
JF - Journal of Pediatrics
IS - 2
ER -