TY - JOUR
T1 - First-pass angiography in mice using FDG-PET
T2 - A simple method of deriving the cardiovascular transit time without the need of region-of-interest drawing
AU - Wu, Hsiao Ming
AU - Kreissl, Michael C.
AU - Schelbert, Heinrich R.
AU - Ladno, Waldemar
AU - Prins, Mayumi
AU - Shoghi-Jadid, Kooresh
AU - Chatziioannou, Arion
AU - Phelps, Michael E.
AU - Huang, Sung Cheng
N1 - Funding Information:
Manuscript received November 1, 2004; revised June 1, 2005. This work was supported in part by DOE cooperative agreement DE-FC03-02ER63420 and NIH Grant RO1-EB001943.
PY - 2005/10
Y1 - 2005/10
N2 - In this study, we developed a simple and robust semi-automatic method to measure the right ventricle to left ventricle (RV-to-LV) transit time (TT) in mice using 2-[ 18F]fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET). The accuracy of the method was first evaluated using a 4-D digital dynamic mouse phantom. The RV-to-LV TTs of twenty-nine mouse studies were measured using the new method and compared to those obtained from the conventional ROI-drawing method. The results showed that the new method correctly separated different structures (e.g., RV, lung, and LV) in the PET images and generated corresponding time activity curve (TAC) of each structure. The RV-to-LV TTs obtained from the new method and ROI method were not statistically different (p = 0.20; r = 0.76). We expect that this fast and robust method is applicable to the pathophysiology of cardiovascular diseases using small animal models such as rats and mice.
AB - In this study, we developed a simple and robust semi-automatic method to measure the right ventricle to left ventricle (RV-to-LV) transit time (TT) in mice using 2-[ 18F]fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET). The accuracy of the method was first evaluated using a 4-D digital dynamic mouse phantom. The RV-to-LV TTs of twenty-nine mouse studies were measured using the new method and compared to those obtained from the conventional ROI-drawing method. The results showed that the new method correctly separated different structures (e.g., RV, lung, and LV) in the PET images and generated corresponding time activity curve (TAC) of each structure. The RV-to-LV TTs obtained from the new method and ROI method were not statistically different (p = 0.20; r = 0.76). We expect that this fast and robust method is applicable to the pathophysiology of cardiovascular diseases using small animal models such as rats and mice.
KW - Cardiovascular transit time
KW - First-pass angiography
KW - Mice
KW - Positron emission tomography
UR - http://www.scopus.com/inward/record.url?scp=29144491486&partnerID=8YFLogxK
U2 - 10.1109/TNS.2005.858239
DO - 10.1109/TNS.2005.858239
M3 - Article
C2 - 26478599
AN - SCOPUS:29144491486
SN - 0018-9499
VL - 52
SP - 1311
EP - 1315
JO - IEEE Transactions on Nuclear Science
JF - IEEE Transactions on Nuclear Science
IS - 5 I
ER -