First- and second-trimester screening for preeclampsia and intrauterine growth restriction

Methodius G. Tuuli, Anthony O. Odibo

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations


Preeclampsia and intrauterine growth restriction are major contributors to perinatal mortality and morbidity. Accurate prediction is important for identifying those women who require more intensive monitoring, permitting earlier recognition and intervention, and allowing targeting of potential preventive measures to those at risk. Although different measures of placental dysfunction have been associated with increased risk adverse pregnancy outcomes, the ability of any single one to accurately predict these outcomes is poor. Attempts to use predictive models combining analytes and measurements of placental structure and blood flow have so far produced mixed results. The use of first- and second-trimester biochemical markers in combination with uterine artery Doppler screening shows promise as potential screening tools. Large prospective studies are needed to further evaluate the choice of parameters and strategies of combination to achieve the best predictive models.

Original languageEnglish
Pages (from-to)727-746
Number of pages20
JournalClinics in Laboratory Medicine
Issue number3
StatePublished - Sep 2010


  • Intrauterine growth restriction
  • Preeclampsia
  • Screening


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