TY - JOUR
T1 - Fine particulate matter exposure and renal function
T2 - A population-based study among pregnant women in China
AU - Zhao, Yan
AU - Cai, Jing
AU - Zhu, Xinlei
AU - van Donkelaar, Aaron
AU - Martin, Randall V.
AU - Hua, Jing
AU - Kan, Haidong
N1 - Publisher Copyright:
© 2020 The Author(s)
PY - 2020/8
Y1 - 2020/8
N2 - Background: Fine particulate matter (PM2.5) is the most serious environmental threat worldwide. The nephrotoxicity of PM2.5 has been demonstrated in older adults, but no study has addressed the impacts of PM2.5 exposure on renal function in pregnant women, who are recognized to be vulnerable and susceptible to PM2.5 exposure. Objective: To evaluate whether exposures to PM2.5 total mass and its chemical constituents were associated with reduced renal function among pregnant women in China. Methods: We measured serum concentrations of urea nitrogen (UN), uric acid (UA) and creatinine for 10,052 pregnant women in Shanghai, China. Exposures to PM2.5 total mass and its 5 key chemical constituents during the whole pregnancy and each trimester of pregnancy was represented by satellite-based models. Results: Exposures to PM2.5 total mass and its chemical constituents of organic matter (OM), black carbon (BC), nitrate (NO3−) and ammonium (NH4+) were positively associated with serum levels of UN and UA, and negatively associated with estimated glomerular filtration rate (eGFR). An interquartile rang (IQR) increase in PM2.5 total mass, OM, BC, NO3– and NH4+ exposure in third trimester was associated with 1.33 (β = -1.33, 95% CI, −1.79, −0.87), 1.67 (β = -1.67, 95% CI, −2.26, −1.07), 1.29 (β = -1.29, 95% CI,-1.89, −0.70), 1.16 (β = -1.16, 95% CI,-1.66, −0.65) and 0.76 (β = -0.76, 95% CI, −1.08, −0.44) mL/min/1.73 m2 decrease in eGFR, respectively. Conclusion: We concluded that exposures to PM2.5 during pregnancy were associated with decreased renal function among pregnant women.
AB - Background: Fine particulate matter (PM2.5) is the most serious environmental threat worldwide. The nephrotoxicity of PM2.5 has been demonstrated in older adults, but no study has addressed the impacts of PM2.5 exposure on renal function in pregnant women, who are recognized to be vulnerable and susceptible to PM2.5 exposure. Objective: To evaluate whether exposures to PM2.5 total mass and its chemical constituents were associated with reduced renal function among pregnant women in China. Methods: We measured serum concentrations of urea nitrogen (UN), uric acid (UA) and creatinine for 10,052 pregnant women in Shanghai, China. Exposures to PM2.5 total mass and its 5 key chemical constituents during the whole pregnancy and each trimester of pregnancy was represented by satellite-based models. Results: Exposures to PM2.5 total mass and its chemical constituents of organic matter (OM), black carbon (BC), nitrate (NO3−) and ammonium (NH4+) were positively associated with serum levels of UN and UA, and negatively associated with estimated glomerular filtration rate (eGFR). An interquartile rang (IQR) increase in PM2.5 total mass, OM, BC, NO3– and NH4+ exposure in third trimester was associated with 1.33 (β = -1.33, 95% CI, −1.79, −0.87), 1.67 (β = -1.67, 95% CI, −2.26, −1.07), 1.29 (β = -1.29, 95% CI,-1.89, −0.70), 1.16 (β = -1.16, 95% CI,-1.66, −0.65) and 0.76 (β = -0.76, 95% CI, −1.08, −0.44) mL/min/1.73 m2 decrease in eGFR, respectively. Conclusion: We concluded that exposures to PM2.5 during pregnancy were associated with decreased renal function among pregnant women.
KW - Ambient air pollution
KW - Chemical constituents
KW - PM
KW - Pregnant woman
KW - Renal function
UR - https://www.scopus.com/pages/publications/85085490821
U2 - 10.1016/j.envint.2020.105805
DO - 10.1016/j.envint.2020.105805
M3 - Article
C2 - 32474297
AN - SCOPUS:85085490821
SN - 0160-4120
VL - 141
JO - Environment International
JF - Environment International
M1 - 105805
ER -