Fine-needle aspiration of brown tumor of bone: Cytologic features with radiologic and histologic correlation

Sasha Pavlovic, Tibor Valyi-Nagy, Jasmina Profirovic, Odile David

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

We report the case of a 40-year-old man with tertiary hyperparathyroidism due to end stage renal disease who initially presented with acute-onset paraplegia, elevated serum parathyroid hormone, and multiple bone abnormalities, including a large extradural intraspinal mass seen by magnetic resonance imaging. In contrast with imaging features, fine-needle aspiration cytology showed numerous benign-appearing multi-nucleated osteoclast-type giant cells that are the characteristics of either brown tumor or benign giant cell tumor of bone. Sheets of mononuclear spindled stromal cells were also noted. A core-needle biopsy confirmed the diagnostic features of brown tumor of hyperparathyroidism.

Original languageEnglish
Pages (from-to)136-139
Number of pages4
JournalDiagnostic cytopathology
Volume37
Issue number2
DOIs
StatePublished - Feb 1 2009

Keywords

  • Brown tumor
  • Cytology
  • Fine-needle aspiration
  • Hyperparathyroidism

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