Finding treasures in frozen cells: New centriole intermediates

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Centriole duplication has been an area of interest since the late 1800s when Boveri suggested that these structures were central organizers for mitosis and cell division. Two groups(1,2) have delineated a linear pathway for centriole assembly. In C. elegans, Pelletier and coworkers(1) have identified intermediates in the pathway using cryo-electron tomography. Surprising, the first intermediate is a hollow tube of 60 nm that increases in diameter and then elongates before acquiring microtubules. Similar structures have not been observed to date in other centrioles.

Original languageEnglish
Pages (from-to)630-634
Number of pages5
Issue number7
StatePublished - Jul 1 2007


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