Finding promoter profiles with multiobjective identification of cis-regulatory modules based on constraints

R. Romero-Zaliz, J. Arnedo-Fdez, I. Zwir, C. Del Val

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Gene expression regulation is an intricate, dynamic phenomenon essential for all biological functions. The necessary instructions for gene expression are encoded in cis-regulatory elements that work together and interact with the RNA polymerase to confer spatial and temporal patterns of transcription. Therefore, the identification of these elements is currently an active area of research in computational analysis of regulatory sequences. However, the problem is difficult since the combinatorial interactions between the regulating factors can be very complex. Here we present a web server that identifies cis-regulatory modules given a set of transcription factor binding sites and, additionally, also RNA polymerase sites for a group of genes.

Original languageEnglish
Title of host publicationProceedings of the 2011 11th International Conference on Intelligent Systems Design and Applications, ISDA'11
Pages1224-1228
Number of pages5
DOIs
StatePublished - Dec 1 2011
Event2011 11th International Conference on Intelligent Systems Design and Applications, ISDA'11 - Cordoba, Spain
Duration: Nov 22 2011Nov 24 2011

Publication series

NameInternational Conference on Intelligent Systems Design and Applications, ISDA
ISSN (Print)2164-7143
ISSN (Electronic)2164-7151

Conference

Conference2011 11th International Conference on Intelligent Systems Design and Applications, ISDA'11
CountrySpain
CityCordoba
Period11/22/1111/24/11

Keywords

  • Multi-objective
  • cis-regulatory modules
  • gene regulation

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    Romero-Zaliz, R., Arnedo-Fdez, J., Zwir, I., & Del Val, C. (2011). Finding promoter profiles with multiobjective identification of cis-regulatory modules based on constraints. In Proceedings of the 2011 11th International Conference on Intelligent Systems Design and Applications, ISDA'11 (pp. 1224-1228). [6121826] (International Conference on Intelligent Systems Design and Applications, ISDA). https://doi.org/10.1109/ISDA.2011.6121826