TY - CHAP
T1 - Finding a Niche
T2 - Tissue Immunity and Innate Lymphoid Cells
AU - Jung, Haerin
AU - Kim, Do Hyun
AU - Wang, Yilin
AU - Van Dyken, Steven J.
N1 - Funding Information:
Acknowledgements We thank members of the Van Dyken laboratory for their insightful comments and discussion. Figures were created with BioRender.com. This work was supported by the US National Institutes of Health (R01 HL148033) and the Department of Pathology and Immunology at Washington University School of Medicine.
Publisher Copyright:
© 2022, The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.
PY - 2022
Y1 - 2022
N2 - The immune system plays essential roles in maintaining homeostasis in mammalian tissues that extend beyond pathogen clearance and host defense. Recently, several homeostatic circuits comprised of paired hematopoietic and non-hematopoietic cells have been described to influence tissue composition and turnover in development and after perturbation. Crucial circuit components include innate lymphoid cells (ILCs), which seed developing organs and shape their resident tissues by influencing progenitor fate decisions, microbial interactions, and neuronal activity. As they develop in tissues, ILCs undergo transcriptional imprinting that encodes receptivity to corresponding signals derived from their resident tissues but ILCs can also shift their transcriptional profiles to adapt to specific types of tissue perturbation. Thus, ILC functions are embedded within their resident tissues, where they constitute key regulators of homeostatic responses that can lead to both beneficial and pathogenic outcomes. Here, we examine the interactions between ILCs and various non-hematopoietic tissue cells, and discuss how specific ILC-tissue cell circuits form essential elements of tissue immunity.
AB - The immune system plays essential roles in maintaining homeostasis in mammalian tissues that extend beyond pathogen clearance and host defense. Recently, several homeostatic circuits comprised of paired hematopoietic and non-hematopoietic cells have been described to influence tissue composition and turnover in development and after perturbation. Crucial circuit components include innate lymphoid cells (ILCs), which seed developing organs and shape their resident tissues by influencing progenitor fate decisions, microbial interactions, and neuronal activity. As they develop in tissues, ILCs undergo transcriptional imprinting that encodes receptivity to corresponding signals derived from their resident tissues but ILCs can also shift their transcriptional profiles to adapt to specific types of tissue perturbation. Thus, ILC functions are embedded within their resident tissues, where they constitute key regulators of homeostatic responses that can lead to both beneficial and pathogenic outcomes. Here, we examine the interactions between ILCs and various non-hematopoietic tissue cells, and discuss how specific ILC-tissue cell circuits form essential elements of tissue immunity.
KW - Cytokines
KW - Innate lymphoid cells
KW - Tissue-resident lymphocytes
KW - Transcriptomics
UR - http://www.scopus.com/inward/record.url?scp=85130069259&partnerID=8YFLogxK
U2 - 10.1007/978-981-16-8387-9_5
DO - 10.1007/978-981-16-8387-9_5
M3 - Chapter
C2 - 35567741
AN - SCOPUS:85130069259
T3 - Advances in Experimental Medicine and Biology
SP - 57
EP - 73
BT - Advances in Experimental Medicine and Biology
PB - Springer
ER -