Final results of the Lung Screening Study, a randomized feasibility study of spiral CT versus chest X-ray screening for lung cancer

John K. Gohagan; Pamela M. Marcus; Richard M. Fagerstrom; Paul F. Pinsky; Barnett S. Kramer; Philip C. Prorok; Susan Ascher; William Bailey; Brenda Brewer; Timothy Church; Deborah Engelhard; Melissa Ford; Mona Fouad; Matthew Freedman; Edward Gelmann; David Gierada; William Hocking; Subbarao Inampudi; Brian Irons; Christine Cole Johnson; Arthur Jones; Gena Kucera; Paul Kvale; Karen Lappe; William Manor; Alisha Moore; Hrudaya Nath; Sarah Neff; Martin Oken; Michael Plunkett; Helen Price; Douglas Reding; Thomas Riley; Martin Schwartz; David Spizarny; Roberta Yoffie; Carl Zylak

doi:10.1016/j.lungcan.2004.06.007

Final results of the Lung Screening Study, a randomized feasibility study of spiral CT versus chest X-ray screening for lung cancer

John K. Gohagan, Pamela M. Marcus, Richard M. Fagerstrom, Paul F. Pinsky, Barnett S. Kramer, Philip C. Prorok, Susan Ascher, William Bailey, Brenda Brewer, Timothy Church, Deborah Engelhard, Melissa Ford, Mona Fouad, Matthew Freedman, Edward Gelmann, David Gierada, William Hocking, Subbarao Inampudi, Brian Irons, Christine Cole JohnsonArthur Jones, Gena Kucera, Paul Kvale, Karen Lappe, William Manor, Alisha Moore, Hrudaya Nath, Sarah Neff, Martin Oken, Michael Plunkett, Helen Price, Douglas Reding, Thomas Riley, Martin Schwartz, David Spizarny, Roberta Yoffie, Carl Zylak

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Abstract

The Lung Screening Study (LSS) was a pilot study designed to assess the feasibility of conducting a large scale randomized controlled trial (RCT) of low radiation dose spiral computed tomography (LDCT) versus chest X-ray (CXR) for lung cancer screening. Baseline results of LSS have been previously reported. Here, we report on the findings at the year one screen and on the final results of the LSS study. A total of 1660 subjects were randomized to the LDCT arm and 1658 to the CXR arm. Compliance with screening declined from 96% at baseline to 86% at year one in the LDCT arm and declined from 93% at baseline to 80% at year one in the CXR arm. Positivity rates for the year one screen were 25.8% for LDCT and 8.7% for CXR. Cancer yield was significantly less at year one for LDCT, 0.57%, than at baseline, 1.9%; cancer yield for CXR increased from 0.45% at baseline to 0.68% at year one. Forty lung cancers in the LDCT arm and 20 in the CXR arm were diagnosed over the study period. Stage I cancers comprised 48% of cases in the LDCT arm and 40% in the CXR arm. A total of 16 stage III-IV cancers were observed in the LDCT arm versus nine in the CXR arm. The LSS has established the feasibility of a RCT comparing annual spiral CT to chest X-ray for lung cancer screening.

Original language	English
Pages (from-to)	9-15
Number of pages	7
Journal	Lung Cancer
Volume	47
Issue number	1
DOIs	https://doi.org/10.1016/j.lungcan.2004.06.007
State	Published - Jan 2005

Keywords

Chest X-ray
Lung cancer
Randomized trial
Screening
Spiral CT

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Gohagan, J. K., Marcus, P. M., Fagerstrom, R. M., Pinsky, P. F., Kramer, B. S., Prorok, P. C., Ascher, S., Bailey, W., Brewer, B., Church, T., Engelhard, D., Ford, M., Fouad, M., Freedman, M., Gelmann, E., Gierada, D., Hocking, W., Inampudi, S., Irons, B., ... Zylak, C. (2005). Final results of the Lung Screening Study, a randomized feasibility study of spiral CT versus chest X-ray screening for lung cancer. Lung Cancer, 47(1), 9-15. https://doi.org/10.1016/j.lungcan.2004.06.007

@article{84d42d23f4a1416c859477a1a1b72685,

title = "Final results of the Lung Screening Study, a randomized feasibility study of spiral CT versus chest X-ray screening for lung cancer",

abstract = "The Lung Screening Study (LSS) was a pilot study designed to assess the feasibility of conducting a large scale randomized controlled trial (RCT) of low radiation dose spiral computed tomography (LDCT) versus chest X-ray (CXR) for lung cancer screening. Baseline results of LSS have been previously reported. Here, we report on the findings at the year one screen and on the final results of the LSS study. A total of 1660 subjects were randomized to the LDCT arm and 1658 to the CXR arm. Compliance with screening declined from 96% at baseline to 86% at year one in the LDCT arm and declined from 93% at baseline to 80% at year one in the CXR arm. Positivity rates for the year one screen were 25.8% for LDCT and 8.7% for CXR. Cancer yield was significantly less at year one for LDCT, 0.57%, than at baseline, 1.9%; cancer yield for CXR increased from 0.45% at baseline to 0.68% at year one. Forty lung cancers in the LDCT arm and 20 in the CXR arm were diagnosed over the study period. Stage I cancers comprised 48% of cases in the LDCT arm and 40% in the CXR arm. A total of 16 stage III-IV cancers were observed in the LDCT arm versus nine in the CXR arm. The LSS has established the feasibility of a RCT comparing annual spiral CT to chest X-ray for lung cancer screening.",

keywords = "Chest X-ray, Lung cancer, Randomized trial, Screening, Spiral CT",

author = "Gohagan, {John K.} and Marcus, {Pamela M.} and Fagerstrom, {Richard M.} and Pinsky, {Paul F.} and Kramer, {Barnett S.} and Prorok, {Philip C.} and Susan Ascher and William Bailey and Brenda Brewer and Timothy Church and Deborah Engelhard and Melissa Ford and Mona Fouad and Matthew Freedman and Edward Gelmann and David Gierada and William Hocking and Subbarao Inampudi and Brian Irons and Johnson, {Christine Cole} and Arthur Jones and Gena Kucera and Paul Kvale and Karen Lappe and William Manor and Alisha Moore and Hrudaya Nath and Sarah Neff and Martin Oken and Michael Plunkett and Helen Price and Douglas Reding and Thomas Riley and Martin Schwartz and David Spizarny and Roberta Yoffie and Carl Zylak",

year = "2005",

month = jan,

doi = "10.1016/j.lungcan.2004.06.007",

language = "English",

volume = "47",

pages = "9--15",

journal = "Lung Cancer",

issn = "0169-5002",

number = "1",

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Gohagan, JK, Marcus, PM, Fagerstrom, RM, Pinsky, PF, Kramer, BS, Prorok, PC, Ascher, S, Bailey, W, Brewer, B, Church, T, Engelhard, D, Ford, M, Fouad, M, Freedman, M, Gelmann, E, Gierada, D, Hocking, W, Inampudi, S, Irons, B, Johnson, CC, Jones, A, Kucera, G, Kvale, P, Lappe, K, Manor, W, Moore, A, Nath, H, Neff, S, Oken, M, Plunkett, M, Price, H, Reding, D, Riley, T, Schwartz, M, Spizarny, D, Yoffie, R & Zylak, C 2005, 'Final results of the Lung Screening Study, a randomized feasibility study of spiral CT versus chest X-ray screening for lung cancer', Lung Cancer, vol. 47, no. 1, pp. 9-15. https://doi.org/10.1016/j.lungcan.2004.06.007

TY - JOUR

T1 - Final results of the Lung Screening Study, a randomized feasibility study of spiral CT versus chest X-ray screening for lung cancer

AU - Gohagan, John K.

AU - Marcus, Pamela M.

AU - Fagerstrom, Richard M.

AU - Pinsky, Paul F.

AU - Kramer, Barnett S.

AU - Prorok, Philip C.

AU - Ascher, Susan

AU - Bailey, William

AU - Brewer, Brenda

AU - Church, Timothy

AU - Engelhard, Deborah

AU - Ford, Melissa

AU - Fouad, Mona

AU - Freedman, Matthew

AU - Gelmann, Edward

AU - Gierada, David

AU - Hocking, William

AU - Inampudi, Subbarao

AU - Irons, Brian

AU - Johnson, Christine Cole

AU - Jones, Arthur

AU - Kucera, Gena

AU - Kvale, Paul

AU - Lappe, Karen

AU - Manor, William

AU - Moore, Alisha

AU - Nath, Hrudaya

AU - Neff, Sarah

AU - Oken, Martin

AU - Plunkett, Michael

AU - Price, Helen

AU - Reding, Douglas

AU - Riley, Thomas

AU - Schwartz, Martin

AU - Spizarny, David

AU - Yoffie, Roberta

AU - Zylak, Carl

PY - 2005/1

Y1 - 2005/1

N2 - The Lung Screening Study (LSS) was a pilot study designed to assess the feasibility of conducting a large scale randomized controlled trial (RCT) of low radiation dose spiral computed tomography (LDCT) versus chest X-ray (CXR) for lung cancer screening. Baseline results of LSS have been previously reported. Here, we report on the findings at the year one screen and on the final results of the LSS study. A total of 1660 subjects were randomized to the LDCT arm and 1658 to the CXR arm. Compliance with screening declined from 96% at baseline to 86% at year one in the LDCT arm and declined from 93% at baseline to 80% at year one in the CXR arm. Positivity rates for the year one screen were 25.8% for LDCT and 8.7% for CXR. Cancer yield was significantly less at year one for LDCT, 0.57%, than at baseline, 1.9%; cancer yield for CXR increased from 0.45% at baseline to 0.68% at year one. Forty lung cancers in the LDCT arm and 20 in the CXR arm were diagnosed over the study period. Stage I cancers comprised 48% of cases in the LDCT arm and 40% in the CXR arm. A total of 16 stage III-IV cancers were observed in the LDCT arm versus nine in the CXR arm. The LSS has established the feasibility of a RCT comparing annual spiral CT to chest X-ray for lung cancer screening.

AB - The Lung Screening Study (LSS) was a pilot study designed to assess the feasibility of conducting a large scale randomized controlled trial (RCT) of low radiation dose spiral computed tomography (LDCT) versus chest X-ray (CXR) for lung cancer screening. Baseline results of LSS have been previously reported. Here, we report on the findings at the year one screen and on the final results of the LSS study. A total of 1660 subjects were randomized to the LDCT arm and 1658 to the CXR arm. Compliance with screening declined from 96% at baseline to 86% at year one in the LDCT arm and declined from 93% at baseline to 80% at year one in the CXR arm. Positivity rates for the year one screen were 25.8% for LDCT and 8.7% for CXR. Cancer yield was significantly less at year one for LDCT, 0.57%, than at baseline, 1.9%; cancer yield for CXR increased from 0.45% at baseline to 0.68% at year one. Forty lung cancers in the LDCT arm and 20 in the CXR arm were diagnosed over the study period. Stage I cancers comprised 48% of cases in the LDCT arm and 40% in the CXR arm. A total of 16 stage III-IV cancers were observed in the LDCT arm versus nine in the CXR arm. The LSS has established the feasibility of a RCT comparing annual spiral CT to chest X-ray for lung cancer screening.

KW - Chest X-ray

KW - Lung cancer

KW - Randomized trial

KW - Screening

KW - Spiral CT

UR - http://www.scopus.com/inward/record.url?scp=10444244070&partnerID=8YFLogxK

U2 - 10.1016/j.lungcan.2004.06.007

DO - 10.1016/j.lungcan.2004.06.007

M3 - Article

C2 - 15603850

AN - SCOPUS:10444244070

SN - 0169-5002

VL - 47

SP - 9

EP - 15

JO - Lung Cancer

JF - Lung Cancer

IS - 1

ER -

Final results of the Lung Screening Study, a randomized feasibility study of spiral CT versus chest X-ray screening for lung cancer

Abstract

Keywords

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