Fim operon variation in the emergence of Enterohemorrhagic Escherichia coli: An evolutionary and functional analysis

Nurmohammad Shaikh; Nicholas J. Holt; James R. Johnson; Phillip I. Tarr

doi:10.1111/j.1574-6968.2007.00781.x

Fim operon variation in the emergence of Enterohemorrhagic Escherichia coli: An evolutionary and functional analysis

Nurmohammad Shaikh
, Nicholas J. Holt
, James R. Johnson
, Phillip I. Tarr

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Fim operons were examined to illuminate the emergence of Escherichia coli O157:H7 from the less-virulent E. coli O55:H7. A fim invertible element deletion occurred only after O157:H7 descended from O55:H7, and after sorbitol nonfermenting O157 diverged. Type 1 pili nonexpression correlates with this deletion in all enterohemorrhagic E. coli (EHEC) tested. An N135K FimH mutation in the two most evolved O157:H7 clusters is not found in other EHEC. These data refine the evolutionary history of an emerging pathogen.

Original language	English
Pages (from-to)	58-63
Number of pages	6
Journal	FEMS Microbiology Letters
Volume	273
Issue number	1
DOIs	https://doi.org/10.1111/j.1574-6968.2007.00781.x
State	Published - Aug 2007

Keywords

Evolution
FimH
Pili

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10.1111/j.1574-6968.2007.00781.x

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title = "Fim operon variation in the emergence of Enterohemorrhagic Escherichia coli: An evolutionary and functional analysis",

abstract = "Fim operons were examined to illuminate the emergence of Escherichia coli O157:H7 from the less-virulent E. coli O55:H7. A fim invertible element deletion occurred only after O157:H7 descended from O55:H7, and after sorbitol nonfermenting O157 diverged. Type 1 pili nonexpression correlates with this deletion in all enterohemorrhagic E. coli (EHEC) tested. An N135K FimH mutation in the two most evolved O157:H7 clusters is not found in other EHEC. These data refine the evolutionary history of an emerging pathogen.",

keywords = "Evolution, FimH, Pili",

author = "Nurmohammad Shaikh and Holt, \{Nicholas J.\} and Johnson, \{James R.\} and Tarr, \{Phillip I.\}",

year = "2007",

month = aug,

doi = "10.1111/j.1574-6968.2007.00781.x",

language = "English",

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journal = "FEMS Microbiology Letters",

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T2 - An evolutionary and functional analysis

AU - Shaikh, Nurmohammad

AU - Holt, Nicholas J.

AU - Johnson, James R.

AU - Tarr, Phillip I.

PY - 2007/8

Y1 - 2007/8

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AB - Fim operons were examined to illuminate the emergence of Escherichia coli O157:H7 from the less-virulent E. coli O55:H7. A fim invertible element deletion occurred only after O157:H7 descended from O55:H7, and after sorbitol nonfermenting O157 diverged. Type 1 pili nonexpression correlates with this deletion in all enterohemorrhagic E. coli (EHEC) tested. An N135K FimH mutation in the two most evolved O157:H7 clusters is not found in other EHEC. These data refine the evolutionary history of an emerging pathogen.

KW - Evolution

KW - FimH

KW - Pili

UR - https://www.scopus.com/pages/publications/34347395737

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DO - 10.1111/j.1574-6968.2007.00781.x

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AN - SCOPUS:34347395737

SN - 0378-1097

VL - 273

SP - 58

EP - 63

JO - FEMS Microbiology Letters

JF - FEMS Microbiology Letters

IS - 1

ER -

Fim operon variation in the emergence of Enterohemorrhagic Escherichia coli: An evolutionary and functional analysis

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Keywords

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