Fim operon variation in the emergence of Enterohemorrhagic Escherichia coli: An evolutionary and functional analysis

Nurmohammad Shaikh, Nicholas J. Holt, James R. Johnson, Phillip I. Tarr

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Fim operons were examined to illuminate the emergence of Escherichia coli O157:H7 from the less-virulent E. coli O55:H7. A fim invertible element deletion occurred only after O157:H7 descended from O55:H7, and after sorbitol nonfermenting O157 diverged. Type 1 pili nonexpression correlates with this deletion in all enterohemorrhagic E. coli (EHEC) tested. An N135K FimH mutation in the two most evolved O157:H7 clusters is not found in other EHEC. These data refine the evolutionary history of an emerging pathogen.

Original languageEnglish
Pages (from-to)58-63
Number of pages6
JournalFEMS Microbiology Letters
Volume273
Issue number1
DOIs
StatePublished - Aug 1 2007

Keywords

  • Evolution
  • FimH
  • Pili

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