Filovirus structural biology: The molecules in the machine

Robert N. Kirchdoerfer, Hal Wasserman, Gaya K. Amarasinghe, Erica Ollmann Saphire

Research output: Chapter in Book/Report/Conference proceedingChapter

10 Scopus citations

Abstract

In this chapter, we describe what is known thus far about the structures and functions of the handful of proteins encoded by filovirus genomes. Amongst the fascinating findings of the last decade is the plurality of functions and structures that these polypeptides can adopt. Many of the encoded proteins can play multiple, distinct roles in the virus life cycle, although the mechanisms by which these functions are determined and controlled remain mostly veiled. Further, some filovirus proteins are multistructural: adopting different oligomeric assemblies and sometimes, different tertiary structures to achieve their separate, and equally essential functions. Structures, and the functions they dictate, are described for components of the nucleocapsid, the matrix, and the surface and secreted glycoproteins.

Original languageEnglish
Title of host publicationCurrent Topics in Microbiology and Immunology
PublisherSpringer Verlag
Pages381-417
Number of pages37
DOIs
StatePublished - Jan 1 2017

Publication series

NameCurrent Topics in Microbiology and Immunology
Volume411
ISSN (Print)0070-217X
ISSN (Electronic)2196-9965

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    Kirchdoerfer, R. N., Wasserman, H., Amarasinghe, G. K., & Saphire, E. O. (2017). Filovirus structural biology: The molecules in the machine. In Current Topics in Microbiology and Immunology (pp. 381-417). (Current Topics in Microbiology and Immunology; Vol. 411). Springer Verlag. https://doi.org/10.1007/82_2017_16