Filovirus pathogenesis and immune evasion: Insights from Ebola virus and Marburg virus

Ilhem Messaoudi, Gaya K. Amarasinghe, Christopher F. Basler

Research output: Contribution to journalReview articlepeer-review

153 Scopus citations

Abstract

Ebola viruses and Marburg viruses, members of the filovirus family, are zoonotic pathogens that cause severe disease in people, as highlighted by the latest Ebola virus epidemic in West Africa. Filovirus disease is characterized by uncontrolled virus replication and the activation of host responses that contribute to pathogenesis. Underlying these phenomena is the potent suppression of host innate antiviral responses, particularly the type I interferon response, by viral proteins, which allows high levels of viral replication. In this Review, we describe the mechanisms used by filoviruses to block host innate immunity and discuss the links between immune evasion and filovirus pathogenesis.

Original languageEnglish
Pages (from-to)663-676
Number of pages14
JournalNature Reviews Microbiology
Volume13
Issue number11
DOIs
StatePublished - Nov 1 2015

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