TY - JOUR
T1 - Filovirus pathogenesis and immune evasion
T2 - Insights from Ebola virus and Marburg virus
AU - Messaoudi, Ilhem
AU - Amarasinghe, Gaya K.
AU - Basler, Christopher F.
N1 - Funding Information:
The authors thank C. Schwall for critical reading of this manuscript. The authors were supported by US National Institutes of Health (NIH) grants U19 AI109945 to C.F.B. (Basler-PI), I.M. and G.K.A.; R01 AI059536 and U19 AI109664 to C.F.B.; and U19 AI070489 (Holtzman-PI) and R01 AI081914 to G.K.A. The authors are also supported by the US Department of Defense and the Defense Threat Reduction Agency grants HDTRA1-12-1-0051 and HDTRA1-14-1-0013 to C.F.B. and G.K.A. The content of this Review does not necessarily reflect the position or the policy of the federal government, and no official endorsement should be inferred.
PY - 2015/11/1
Y1 - 2015/11/1
N2 - Ebola viruses and Marburg viruses, members of the filovirus family, are zoonotic pathogens that cause severe disease in people, as highlighted by the latest Ebola virus epidemic in West Africa. Filovirus disease is characterized by uncontrolled virus replication and the activation of host responses that contribute to pathogenesis. Underlying these phenomena is the potent suppression of host innate antiviral responses, particularly the type I interferon response, by viral proteins, which allows high levels of viral replication. In this Review, we describe the mechanisms used by filoviruses to block host innate immunity and discuss the links between immune evasion and filovirus pathogenesis.
AB - Ebola viruses and Marburg viruses, members of the filovirus family, are zoonotic pathogens that cause severe disease in people, as highlighted by the latest Ebola virus epidemic in West Africa. Filovirus disease is characterized by uncontrolled virus replication and the activation of host responses that contribute to pathogenesis. Underlying these phenomena is the potent suppression of host innate antiviral responses, particularly the type I interferon response, by viral proteins, which allows high levels of viral replication. In this Review, we describe the mechanisms used by filoviruses to block host innate immunity and discuss the links between immune evasion and filovirus pathogenesis.
UR - http://www.scopus.com/inward/record.url?scp=84944511031&partnerID=8YFLogxK
U2 - 10.1038/nrmicro3524
DO - 10.1038/nrmicro3524
M3 - Review article
C2 - 26439085
AN - SCOPUS:84944511031
SN - 1740-1526
VL - 13
SP - 663
EP - 676
JO - Nature Reviews Microbiology
JF - Nature Reviews Microbiology
IS - 11
ER -