Fifty Shades of Microglia

Simone Brioschi; Vincent Peng; Marco Colonna

doi:10.1016/j.tins.2019.03.010

Fifty Shades of Microglia

Simone Brioschi, Vincent Peng, Marco Colonna

Research output: Contribution to journal › Short survey › peer-review

8 Scopus citations

Abstract

In a recent study, Masuda and colleagues (Nature 2019;566:388–392) used single-cell RNA-sequencing (scRNA-seq) to profile microglia across different anatomical compartments, developmental stages, and types of brain pathology in mice. Moreover, the authors performed a novel transcriptomic characterization of microglia from multiple sclerosis patients and identified phenotypically conserved microglial subsets between species. These findings, together with seminal prior results from various groups, provide valuable insights into the spatiotemporal heterogeneity of microglia during brain development and disease.

Original language	English
Pages (from-to)	440-443
Number of pages	4
Journal	Trends in Neurosciences
Volume	42
Issue number	7
DOIs	https://doi.org/10.1016/j.tins.2019.03.010
State	Published - Jul 2019

Keywords

cuprizone model
facial nerve axotomy
microglial transcriptomic signature
mouse and human microglia
multiple sclerosis
single-cell RNA sequencing

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10.1016/j.tins.2019.03.010

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title = "Fifty Shades of Microglia",

abstract = "In a recent study, Masuda and colleagues (Nature 2019;566:388–392) used single-cell RNA-sequencing (scRNA-seq) to profile microglia across different anatomical compartments, developmental stages, and types of brain pathology in mice. Moreover, the authors performed a novel transcriptomic characterization of microglia from multiple sclerosis patients and identified phenotypically conserved microglial subsets between species. These findings, together with seminal prior results from various groups, provide valuable insights into the spatiotemporal heterogeneity of microglia during brain development and disease.",

keywords = "cuprizone model, facial nerve axotomy, microglial transcriptomic signature, mouse and human microglia, multiple sclerosis, single-cell RNA sequencing",

author = "Simone Brioschi and Vincent Peng and Marco Colonna",

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year = "2019",

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AU - Peng, Vincent

AU - Colonna, Marco

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AB - In a recent study, Masuda and colleagues (Nature 2019;566:388–392) used single-cell RNA-sequencing (scRNA-seq) to profile microglia across different anatomical compartments, developmental stages, and types of brain pathology in mice. Moreover, the authors performed a novel transcriptomic characterization of microglia from multiple sclerosis patients and identified phenotypically conserved microglial subsets between species. These findings, together with seminal prior results from various groups, provide valuable insights into the spatiotemporal heterogeneity of microglia during brain development and disease.

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KW - facial nerve axotomy

KW - microglial transcriptomic signature

KW - mouse and human microglia

KW - multiple sclerosis

KW - single-cell RNA sequencing

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JO - Trends in Neurosciences

JF - Trends in Neurosciences

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ER -

Fifty Shades of Microglia

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Keywords

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