TY - JOUR
T1 - Fifty Shades of Microglia
AU - Brioschi, Simone
AU - Peng, Vincent
AU - Colonna, Marco
N1 - Funding Information:
This work was supported by NIH ( RF1AG05148501 ) and the Cure Alzheimer’s Fund .
Funding Information:
This work was supported by NIH (RF1AG05148501) and the Cure Alzheimer's Fund. Marco Colonna is the recipient of research funds from Alector, Amgen, and Ono.
Publisher Copyright:
© 2019 Elsevier Ltd
PY - 2019/7
Y1 - 2019/7
N2 - In a recent study, Masuda and colleagues (Nature 2019;566:388–392) used single-cell RNA-sequencing (scRNA-seq) to profile microglia across different anatomical compartments, developmental stages, and types of brain pathology in mice. Moreover, the authors performed a novel transcriptomic characterization of microglia from multiple sclerosis patients and identified phenotypically conserved microglial subsets between species. These findings, together with seminal prior results from various groups, provide valuable insights into the spatiotemporal heterogeneity of microglia during brain development and disease.
AB - In a recent study, Masuda and colleagues (Nature 2019;566:388–392) used single-cell RNA-sequencing (scRNA-seq) to profile microglia across different anatomical compartments, developmental stages, and types of brain pathology in mice. Moreover, the authors performed a novel transcriptomic characterization of microglia from multiple sclerosis patients and identified phenotypically conserved microglial subsets between species. These findings, together with seminal prior results from various groups, provide valuable insights into the spatiotemporal heterogeneity of microglia during brain development and disease.
KW - cuprizone model
KW - facial nerve axotomy
KW - microglial transcriptomic signature
KW - mouse and human microglia
KW - multiple sclerosis
KW - single-cell RNA sequencing
UR - http://www.scopus.com/inward/record.url?scp=85064314513&partnerID=8YFLogxK
U2 - 10.1016/j.tins.2019.03.010
DO - 10.1016/j.tins.2019.03.010
M3 - Short survey
C2 - 31005331
AN - SCOPUS:85064314513
SN - 0166-2236
VL - 42
SP - 440
EP - 443
JO - Trends in Neurosciences
JF - Trends in Neurosciences
IS - 7
ER -