In a recent study, Masuda and colleagues (Nature 2019;566:388–392) used single-cell RNA-sequencing (scRNA-seq) to profile microglia across different anatomical compartments, developmental stages, and types of brain pathology in mice. Moreover, the authors performed a novel transcriptomic characterization of microglia from multiple sclerosis patients and identified phenotypically conserved microglial subsets between species. These findings, together with seminal prior results from various groups, provide valuable insights into the spatiotemporal heterogeneity of microglia during brain development and disease.

Original languageEnglish
Pages (from-to)440-443
Number of pages4
JournalTrends in Neurosciences
Issue number7
StatePublished - Jul 2019


  • cuprizone model
  • facial nerve axotomy
  • microglial transcriptomic signature
  • mouse and human microglia
  • multiple sclerosis
  • single-cell RNA sequencing


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