Fifty Shades of Microglia

Simone Brioschi, Vincent Peng, Marco Colonna

Research output: Contribution to journalShort survey

1 Scopus citations

Abstract

In a recent study, Masuda and colleagues (Nature 2019;566:388–392) used single-cell RNA-sequencing (scRNA-seq) to profile microglia across different anatomical compartments, developmental stages, and types of brain pathology in mice. Moreover, the authors performed a novel transcriptomic characterization of microglia from multiple sclerosis patients and identified phenotypically conserved microglial subsets between species. These findings, together with seminal prior results from various groups, provide valuable insights into the spatiotemporal heterogeneity of microglia during brain development and disease.

Original languageEnglish
Pages (from-to)440-443
Number of pages4
JournalTrends in Neurosciences
Volume42
Issue number7
DOIs
StatePublished - Jul 2019

Keywords

  • cuprizone model
  • facial nerve axotomy
  • microglial transcriptomic signature
  • mouse and human microglia
  • multiple sclerosis
  • single-cell RNA sequencing

Fingerprint Dive into the research topics of 'Fifty Shades of Microglia'. Together they form a unique fingerprint.

  • Cite this