TY - JOUR
T1 - Fifteen compelling open questions in plant cell biology
AU - Roeder, Adrienne H.K.
AU - Otegui, Marisa S.
AU - Dixit, Ram
AU - Anderson, Charles T.
AU - Faulkner, Christine
AU - Zhang, Yan
AU - Harrison, Maria J.
AU - Kirchhelle, Charlotte
AU - Goshima, Gohta
AU - Coate, Jeremy E.
AU - Doyle, Jeff J.
AU - Hamant, Olivier
AU - Sugimoto, Keiko
AU - Dolan, Liam
AU - Meyer, Heather
AU - Ehrhardt, David W.
AU - Boudaoud, Arezki
AU - Messina, Carlos
N1 - Funding Information:
This work was supported by the Simons Foundation-Life Science Research Foundation [Meyer LSRF18/Carnegie Fund 10861] and the Carnegie Institution for Science.
Funding Information:
and National Institute of General Medical Sciences of the National Institutes of Health under award number R35GM139552.
Funding Information:
Research in the Roeder lab is supported by the National Institute of General Medical Sciences of the National Institutes of Health under Award Number R01GM134037 to AHKR and the National Science Foundation (NSF) IOS 1553030 to AHKR.
Funding Information:
The work in my laboratory is supported by grants from Ministry of Education, Culture, Sports, and Technology of Japan (20H03284 and 20H05911).
Funding Information:
Work on endosomal trafficking in the Otegui Lab is supported by grant National Science Foundation (NSF) MCB2114603 to MSO.
Funding Information:
Research in my laboratory is funded by the European Research Council Advanced Grant (Contract 787613) and the Austrian Academy of Sciences.
Funding Information:
This work was supported by the Center for Engineering Mechanobiology, a National Science Foundation Science and Technology Center, under grant agreement CMMI: 15-48571
Funding Information:
Research in the Faulkner lab is supported by the Biotechnology and Biological Research Council Grant (BB/ L000466/1, BBS/E/J/000PR9796) and the European Research Council (725459, “INTERCELLAR”).
Funding Information:
Research in the author’s lab is supported by the National Science Foundation (NSF IOS-2139351) and the Office of Science (BER), US Department of Energy (DOE-SC0014395).
Funding Information:
This work was supported as part of The Center for Lignocellulose Structure and Formation, an Energy Frontier Research Center funded by the US Department of Energy, Office of Science, Basic Energy Sciences under Award # DESC0001090.
Funding Information:
Work on vacuolar dynamics in the Zhang Lab is supported by the National Science Foundation of China (NSFC) (grant number 31625003, 31970332).
Funding Information:
I acknowledge funding from the Biotechnology and Biological Sciences Research Council (BB/P01979X/1) and the Leverhulme Trust (ECF-2017-483).
Publisher Copyright:
© The Author(s) 2021. Published by Oxford University Press on behalf of American Society of Plant Biologists.
PY - 2022/1
Y1 - 2022/1
N2 - As scientists, we are at least as excited about the open questions-the things we do not know-as the discoveries. Here, we asked 15 experts to describe the most compelling open questions in plant cell biology. These are their questions: How are organelle identity, domains, and boundaries maintained under the continuous flux of vesicle trafficking and membrane remodeling? Is the plant cortical microtubule cytoskeleton a mechanosensory apparatus? How are the cellular pathways of cell wall synthesis, assembly, modification, and integrity sensing linked in plants? Why do plasmodesmata open and close? Is there retrograde signaling from vacuoles to the nucleus? How do root cells accommodate fungal endosymbionts? What is the role of cell edges in plant morphogenesis? How is the cell division site determined? What are the emergent effects of polyploidy on the biology of the cell, and how are any such “rules” conditioned by cell type? Can mechanical forces trigger new cell fates in plants? How does a single differentiated somatic cell reprogram and gain pluripotency? How does polarity develop de-novo in isolated plant cells? What is the spectrum of cellular functions for membraneless organelles and intrinsically disordered proteins? How do plants deal with internal noise? How does order emerge in cells and propagate to organs and organisms from complex dynamical processes? We hope you find the discussions of these questions thought provoking and inspiring.
AB - As scientists, we are at least as excited about the open questions-the things we do not know-as the discoveries. Here, we asked 15 experts to describe the most compelling open questions in plant cell biology. These are their questions: How are organelle identity, domains, and boundaries maintained under the continuous flux of vesicle trafficking and membrane remodeling? Is the plant cortical microtubule cytoskeleton a mechanosensory apparatus? How are the cellular pathways of cell wall synthesis, assembly, modification, and integrity sensing linked in plants? Why do plasmodesmata open and close? Is there retrograde signaling from vacuoles to the nucleus? How do root cells accommodate fungal endosymbionts? What is the role of cell edges in plant morphogenesis? How is the cell division site determined? What are the emergent effects of polyploidy on the biology of the cell, and how are any such “rules” conditioned by cell type? Can mechanical forces trigger new cell fates in plants? How does a single differentiated somatic cell reprogram and gain pluripotency? How does polarity develop de-novo in isolated plant cells? What is the spectrum of cellular functions for membraneless organelles and intrinsically disordered proteins? How do plants deal with internal noise? How does order emerge in cells and propagate to organs and organisms from complex dynamical processes? We hope you find the discussions of these questions thought provoking and inspiring.
UR - http://www.scopus.com/inward/record.url?scp=85122281747&partnerID=8YFLogxK
U2 - 10.1093/plcell/koab225
DO - 10.1093/plcell/koab225
M3 - Review article
C2 - 34529074
AN - SCOPUS:85122281747
SN - 1040-4651
VL - 34
SP - 72
EP - 102
JO - Plant Cell
JF - Plant Cell
IS - 1
ER -