Fidelity of T cell activation through multistep T cell receptor ζ phosphorylation

Ellen Neumeister Kersh, Andrey S. Shaw, Paul M. Allen

Research output: Contribution to journalArticlepeer-review

300 Scopus citations

Abstract

The T cell receptor (TCR) αβ heterodimer interacts with its ligands with high specificity, but surprisingly low affinity. The role of the ζ component of the murine TCR in contributing to the fidelity of antigen recognition was examined. With sequence-specific phosphotyrosine antibodies, it was found that ζ undergoes a series of ordered phosphorylation events upon TCR engagement. Completion of phosphorylation steps is dependent on the nature of the TCR ligand. Thus, the phosphorylation steps establish thresholds for T cell activation. This study documents the sophisticated molecular events that follow the engagement of a low-affinity receptor.

Original languageEnglish
Pages (from-to)572-575
Number of pages4
JournalScience
Volume281
Issue number5376
DOIs
StatePublished - Jul 24 1998

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