Fibrotic Changes Mediating Acute Kidney Injury to Chronic Kidney Disease Transition

Eoghainín Ó Hainmhire, Benjamin D. Humphreys

Research output: Contribution to journalReview article

6 Scopus citations

Abstract

End-stage renal disease (ESRD) is common, costly, and it results from progressive chronic kidney disease (CKD). ESRD claims many lives every year. It is increasingly recognized that episodes of acute kidney injury (AKI) predispose to the future development of CKD and ESRD. While our understanding of the pathophysiology of the AKI to CKD transition is improving, there are no validated therapeutic strategies to prevent this transition. In this review, we summarize the recent progress made in defining the cellular and molecular events underlying the AKI to CKD transition and highlight potential therapeutic targets and strategies to reduce the incidence of CKD following AKI.

Original languageEnglish
Pages (from-to)264-267
Number of pages4
JournalNephron
Volume137
Issue number4
DOIs
StatePublished - Nov 1 2017

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