Fibroblast growth factors (FGFs) and their receptors (FGFRs) are expressed throughout all stages of skeletal development. In the limb bud and in cranial mesenchyme, FGF signaling is important for formation of mesenchymal condensations that give rise to bone. Once skeletal elements are initiated and patterned, FGFs regulate both endochondral and intramembranous ossification programs. In this chapter, we review functions of the FGF signaling pathway during these critical stages of skeletogenesis, and explore skeletal malformations in humans that are caused by mutations in FGF signaling molecules.

Original languageEnglish
Title of host publicationVertebrate Skeletal Development
EditorsBjorn R. Olsen
PublisherAcademic Press Inc.
Number of pages40
ISBN (Print)9780128104873
StatePublished - Jan 1 2019

Publication series

NameCurrent Topics in Developmental Biology
ISSN (Print)0070-2153


  • Chondrocyte
  • Chondrodysplasia
  • Craniosynostosis
  • Endochondral ossification
  • Fibroblast growth factor receptors
  • Fibroblast growth factors
  • Heparan sulfate proteoglycans
  • Intracellular signaling
  • Intramembranous ossification
  • Osteoblast
  • Receptor tyrosine kinase


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