@inbook{b5dd14051d68441e8b564cf121deef4d,
title = "Fibroblast growth factors in skeletal development",
abstract = "Fibroblast growth factors (FGFs) and their receptors (FGFRs) are expressed throughout all stages of skeletal development. In the limb bud and in cranial mesenchyme, FGF signaling is important for formation of mesenchymal condensations that give rise to bone. Once skeletal elements are initiated and patterned, FGFs regulate both endochondral and intramembranous ossification programs. In this chapter, we review functions of the FGF signaling pathway during these critical stages of skeletogenesis, and explore skeletal malformations in humans that are caused by mutations in FGF signaling molecules.",
keywords = "Chondrocyte, Chondrodysplasia, Craniosynostosis, Endochondral ossification, Fibroblast growth factor receptors, Fibroblast growth factors, Heparan sulfate proteoglycans, Intracellular signaling, Intramembranous ossification, Osteoblast, Receptor tyrosine kinase",
author = "Ornitz, {David M.} and Marie, {Pierre J.}",
note = "Funding Information: The authors thank all team members who contributed to the work reviewed in this chapter. The authors apologize to the investigators whose work could not be cited due to space limitations. This work was supported by NIH grant HD049808 (D.M.O.), by the Department of Developmental Biology at Washington University, and by the Institut National de la Recherche M{\'e}dicale (Inserm), University Paris Diderot Sorbonne Paris Cit{\'e}, the DIM Stem P{\^o}le Ile de France, the French Minister of Research and the Asssociation Pr{\'e}vention et Traitement des D{\'e}calcifications (Paris, France) (P.J.M.). Funding Information: The authors thank all team members who contributed to the work reviewed in this chapter. The authors apologize to the investigators whose work could not be cited due to space limitations. This work was supported by NIH grant HD049808 (D.M.O.), by the Department of Developmental Biology at Washington University, and by the Institut National de la Recherche M?dicale (Inserm), University Paris Diderot Sorbonne Paris Cit? the DIM Stem P?le Ile de France, the French Minister of Research and the Asssociation Pr?vention et Traitement des D?calcifications (Paris, France) (P.J.M.). Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",
year = "2019",
month = jan,
day = "1",
doi = "10.1016/bs.ctdb.2018.11.020",
language = "English",
isbn = "9780128104873",
series = "Current Topics in Developmental Biology",
publisher = "Academic Press Inc.",
pages = "195--234",
editor = "Olsen, {Bjorn R.}",
booktitle = "Vertebrate Skeletal Development",
}