Fibroblast growth factor signaling in skeletal development and disease

David M. Ornitz, Pierre J. Marie

Research output: Contribution to journalReview articlepeer-review

201 Scopus citations

Abstract

Fibroblast growth factor (FGF) signaling pathways are essential regulators of vertebrate skeletal development. FGF signaling regulates development of the limb bud and formation of the mesenchymal condensation and has key roles in regulating chondrogenesis, osteogenesis, and bone and mineral homeostasis. This review updates our review on FGFs in skeletal development published in Genes & Development in 2002, examines progress made on understanding the functions of the FGF signaling pathway during critical stages of skeletogenesis, and explores the mechanisms by which mutations in FGF signaling molecules cause skeletal malformations in humans. Links between FGF signaling pathways and other interacting pathways that are critical for skeletal development and could be exploited to treat genetic diseases and repair bone are also explored.

Original languageEnglish
Pages (from-to)1463-1486
Number of pages24
JournalGenes and Development
Volume29
Issue number14
DOIs
StatePublished - Jul 15 2015

Keywords

  • Bone
  • Cartilage
  • Chondrocyte
  • FGF
  • FGFR
  • Osteoblast

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