Fibroblast growth factor receptor signalling is crucial for liver homeostasis and regeneration

Heike Steiling, Torsten Wüstefeld, Philippe Bugnon, Maria Brauchle, Reinhard Fässler, Daniel Teupser, Joachim Thiery, Jeffrey I. Gordon, Christian Trautwein, Sabine Werner

Research output: Contribution to journalArticlepeer-review

59 Scopus citations

Abstract

Several growth factors have been suggested to play a crucial role in liver regeneration, but a functional proof is still missing. Since fibroblast growth factors are important for the initiation of mammalian liver development, we determined the roles of these mitogens in liver repair by targeted expression of a dominant-negative fibroblast growth factor receptor (FGFR) in hepatocytes of transgenic mice. The liver of young animals appeared histologically normal, and liver function was not obviously impaired. In aged transgenic mice, the frequency of fatty liver development was strongly increased compared to control animals. Following partial hepatectomy, transgenic mice showed markedly reduced hepatocyte proliferation because of an arrest in the late G1 phase of the cell cycle. These data demonstrate a key role of FGFR signalling in repair after liver injury.

Original languageEnglish
Pages (from-to)4380-4388
Number of pages9
JournalOncogene
Volume22
Issue number28
DOIs
StatePublished - Jul 10 2003

Keywords

  • Cell cycle
  • Hepatectomy
  • Injury
  • Keratinocyte growth factor
  • Regeneration
  • Steatosis

Fingerprint Dive into the research topics of 'Fibroblast growth factor receptor signalling is crucial for liver homeostasis and regeneration'. Together they form a unique fingerprint.

Cite this