Fibroblast growth factor (FGF) and FGF receptor families in bone

Pierre J. Marie; Marja Hurley; David M. Ornitz

doi:10.1016/B978-0-12-814841-9.00045-2

Fibroblast growth factor (FGF) and FGF receptor families in bone

Pierre J. Marie, Marja Hurley, David M. Ornitz

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

1 Scopus citations

Abstract

Fibroblast growth factors (FGFs) play essential roles during skeletal development and in the regulation of postnatal chondrogenesis and osteogenesis. This chapter updates our current knowledge of the expression of FGFs and FGF receptors (FGFRs) during development and postnatal skeletogenesis, describes the role of FGFs in the regulation of bone and other tissues, and reviews the functions of FGF/FGFR signaling in skeletal growth, bone formation and resorption, bone remodeling, and repair. We also update the mechanisms by which mutations in FGFRs induce abnormalities in chondrogenesis and osteogenesis in skeletal dysplasias and review how this knowledge may be exploited to treat genetic bone diseases associated with FGFR mutations.

Original language	English
Title of host publication	Principles of Bone Biology
Publisher	Elsevier
Pages	1113-1140
Number of pages	28
ISBN (Electronic)	9780128148419
DOIs	https://doi.org/10.1016/B978-0-12-814841-9.00045-2
State	Published - Jan 1 2019

Keywords

Bone formation
Bone repair
Bone resorption
Chondrodysplasias
Chondrogenesis
Craniosynostosis
Fibroblast growth factor receptors
Fibroblast growth factors
Osteogenesis
Signaling
Treatments

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10.1016/B978-0-12-814841-9.00045-2

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abstract = "Fibroblast growth factors (FGFs) play essential roles during skeletal development and in the regulation of postnatal chondrogenesis and osteogenesis. This chapter updates our current knowledge of the expression of FGFs and FGF receptors (FGFRs) during development and postnatal skeletogenesis, describes the role of FGFs in the regulation of bone and other tissues, and reviews the functions of FGF/FGFR signaling in skeletal growth, bone formation and resorption, bone remodeling, and repair. We also update the mechanisms by which mutations in FGFRs induce abnormalities in chondrogenesis and osteogenesis in skeletal dysplasias and review how this knowledge may be exploited to treat genetic bone diseases associated with FGFR mutations.",

keywords = "Bone formation, Bone repair, Bone resorption, Chondrodysplasias, Chondrogenesis, Craniosynostosis, Fibroblast growth factor receptors, Fibroblast growth factors, Osteogenesis, Signaling, Treatments",

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AB - Fibroblast growth factors (FGFs) play essential roles during skeletal development and in the regulation of postnatal chondrogenesis and osteogenesis. This chapter updates our current knowledge of the expression of FGFs and FGF receptors (FGFRs) during development and postnatal skeletogenesis, describes the role of FGFs in the regulation of bone and other tissues, and reviews the functions of FGF/FGFR signaling in skeletal growth, bone formation and resorption, bone remodeling, and repair. We also update the mechanisms by which mutations in FGFRs induce abnormalities in chondrogenesis and osteogenesis in skeletal dysplasias and review how this knowledge may be exploited to treat genetic bone diseases associated with FGFR mutations.

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KW - Bone repair

KW - Bone resorption

KW - Chondrodysplasias

KW - Chondrogenesis

KW - Craniosynostosis

KW - Fibroblast growth factor receptors

KW - Fibroblast growth factors

KW - Osteogenesis

KW - Signaling

KW - Treatments

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BT - Principles of Bone Biology

PB - Elsevier

ER -

Fibroblast growth factor (FGF) and FGF receptor families in bone

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